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Interspecies pharmacokinetic scaling of metazosin, a novel alpha-adrenergic antagonist.
- R. Lapka, V. Rejholec, T. Sechser, M. Peterková, M. Šmíd
- Chemistry, Medicine
- Biopharmaceutics & drug disposition
- 1 November 1989
Based on pharmacokinetic data from mice, rats, and rabbits, the prediction of pharmacokinetics of intravenous metazosin in man has been performed. The correlations were based upon allometric scaling… Expand
Regulatory mutants of Streptomyces cinnamonensis producing monensin A
We prepared mutants of Streptomyces cinnamonensis resistant to amino acid analogues: 2-aminobutyrate, norvaline, norleucine, 2-amino-3-chlorobutyrate and ethionine. The regulatory mutants were… Expand
[Densitometric determination of prazosin in plasma].
[Fluorimetric determination of cephalexin].
Pharmacokinetics and pharmacodynamics of conventional and controlled-release formulations of metipranolol in man
- R. Lapka, T. Sechser, V. Rejholec, M. Peterková, M. Votavová
- European Journal of Clinical Pharmacology
SummaryThe pharmacokinetics and β-adrenoceptor blocking effects of conventional and sustained-release metipranolol have been studied in 6 healthy male volunteers given a single oral dose of 40 mg.… Expand
[Derivatives of benzo(c)fluorene. XVII. Pharmacokinetics of benfluron in animals].
[Densitometric determination of desacetylmetipranolol in blood plasma].
[Spectrophotometric determination of cephalexin].
Some Hemostatic Changes During the Course of Hemodialysis in Patients with Erythropoietin Treatment
The recombinant human erythropoietin (rHuEPO), an effective agent in the treatment of renal anemia, can predispose chronic uremic patients to thrombotic events with regular hemodialysis (HD). It has… Expand
[Serum ferritin in patients with chronic kidney failure. I].