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Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling.
Unlike humans, who have a continuous row of teeth, mice have only molars and incisors separated by a toothless region called a diastema. Although tooth buds form in the embryonic diastema, theyExpand
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An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors
Rodent incisors grow throughout adult life, but are prevented from becoming excessively long by constant abrasion, which is facilitated by the absence of enamel on one side of the incisor. Here weExpand
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Chick embryotoxicity screening test--130 substances tested.
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Epigenetic Signals during Odontoblast Differentiation
Odontoblast terminal differentiation occurs according to a tooth-specific pattern and implies both temporo-spatially regulated epigenetic signaling and the expression of specific competence.Expand
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Developmental disorders of the dentition: An update
Dental anomalies are common congenital malformations that can occur either as isolated findings or as part of a syndrome. This review focuses on genetic causes of abnormal tooth development and theExpand
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Tooth size in children with cleft lip and palate.
The mesiodistal and buccolingual dimensions of primary and permanent teeth were measured in 246 children with either isolated cleft palate or complete unilateral cleft lip and palate. The primaryExpand
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Patterning by heritage in mouse molar row development
It is known from paleontology studies that two premolars have been lost during mouse evolution. During mouse mandible development, two bud-like structures transiently form that may representExpand
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Timing of exchange of the maxillary deciduous and permanent teeth in boys with three types of orofacial clefts.
Timing of exchange of the deciduous and permanent maxillary teeth was investigated using dental plaster casts of 163 boys with total unilateral cleft (UCLP), 82 boys with bilateral cleft (BCLP), andExpand
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Mouse molar morphogenesis revisited by three-dimensional reconstruction. II. Spatial distribution of mitoses and apoptosis in cap to bell staged first and second upper molar teeth.
Tooth morphogenesis is a complex multifactorial process in which differential mitotic activities and cell death play important roles. Upper first (m1) and second (m2) molars from mouse embryos wereExpand
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Development of the Vestigial Tooth Primordia as Part of Mouse Odontogenesis
The mouse functional dentition comprises one incisor separated from three molars by a toothless diastema in each dental quadrant. Between the incisor and molars, the embryonic tooth pattern alsoExpand
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