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Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans.
TLDR
The experiments suggest that NO may play both vascular regulatory and host defence roles in pulmonary physiology and pathophysiology. Expand
Single-breath nitric oxide measurements in asthmatic patients and smokers
TLDR
The findings support a role for NO in the host defence response in asthma and suggest that NO measurements can discriminate between different types of lung disorders. Expand
Positive End-Expiratory Pressure Ventilation Elicits Increases in Endogenously Formed Nitric Oxide as Detected in Air Exhaled by Rabbits
TLDR
PEEP elicited dose-dependent and reproducible increments in exhaled NO and in arterial oxygen tension (PaO2), perhaps by a stretch-dependent effect on the respiratory system. Expand
Contribution from upper and lower airways to exhaled endogenous nitric oxide in humans
TLDR
The aim was to study the excretion of NO in different parts of the respiratory system, including pulmonary circulation and bronchomotion. Expand
Lung distension and carbon dioxide affect pulmonary nitric oxide formation in the anaesthetized rabbit.
TLDR
The observations of lung distension effects on exhaled NO suggest the possibility of stretch receptors or -receptive mechanisms coupled to NO formation within the lung. Expand
Pigment-dispersing factor in the locust abdominal ganglia may have roles as circulating neurohormone and central neuromodulator.
TLDR
Pigment-dispersing factor seems to have a modulatory role in central neuronal circuits of the terminal abdominal ganglion that control muscles of genital organs. Expand
Endogenous nitric oxide in single exhalations and the change during exercise.
TLDR
The data are compatible with the hypothesis that the NO detected in exhaled air is formed preferentially in the terminal and respiratory bronchioles, and they suggest increased production of NO into exhale air during exercise and during hyperventilation at rest. Expand
The promotion of patent airways and inhibition of antigen‐induced bronchial obstruction by endogenous nitric oxide
TLDR
The results indicate that endogenous NO has an inhibitory effect on bronchial obstruction and increased NO release during allergen challenge is likely to be due to actions of histamine and leukotrienes. Expand
Modulation of autonomic neuroeffector transmission by nitric oxide in guinea pig ileum.
TLDR
NG-monomethyl-L-arginine, an inhibitor of nitric oxide synthesis, markedly enhanced tonic responses to transmural stimulation in guinea pig ileum longitudinal muscle, and selectively modulates peptidergic neurotransmission in the gut. Expand
Direct demonstration of NO formation in vivo from organic nitrites and nitrates, and correlation to effects on blood pressure and to in vitro effects.
TLDR
Organic nitrites and organic nitrates can modulate adrenergic neuroeffector transmission in guinea pig pulmonary artery and vas deferens, and produce detectable concentrations of nitric oxide in exhaled air in vivo, in the rabbit. Expand
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