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A novel endothelial-derived lipase that modulates HDL metabolism
TLDR
The cloning and in vivo functional analysis of a new member of the TG lipase family that is synthesized by endothelial cells in vitro and thus has been termed endothelial lipase (encoded by the LIPG gene) suggests that it may have a role in lipoprotein metabolism and vascular biology. Expand
Cardioprotective effects of the novel adenosine A1/A2 receptor agonist AMP 579 in a porcine model of myocardial infarction.
TLDR
The cardioprotective effects and pharmacology of the novel adenosine A1/A2 receptor agonist AMP 579 are examined, showing its potential utility in the treatment of acute myocardial infarction. Expand
Angiotensin type 2 receptors mediate depressor phase of biphasic pressure response to angiotensin.
TLDR
It is demonstrated that the AT2 receptors mediate a depressor response to ANG, which caused consistent decreases in pressure during AT1 receptor blockade and was inhibited during combined blockade of AT1 and AT1 receptors. Expand
Evidence for L-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers.
TLDR
Microinjection of L-glutamate into the intermediate nucleus tractus solitarii in anesthetized rats elicits hypotension, bradycardia, and apnea, simulating baroreceptor reflexes, which indicates that L-Glutamate may be the neurotransmitter of afferent nerve fibers from arterial baroreceptors. Expand
Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis.
TLDR
Structural modifications on YM 175 to enhance cell permeability may result in a new class of cholesterol-lowering agents. Expand
Acute Hypertension after the Local Injection of Kainic Acid into the Nucleus Tractus Solitarii of Rats
TLDR
The results suggest that fulminating hypertension can be produced by nondestructive perturbations of neurochemical transmission in brain and adds further support to the hypothesis that L-glutamate is the neurotransmitter released by baroreceptor afferent nerves. Expand
Demonstration of vasorelaxant activity with an A1-selective adenosine agonist in porcine coronary artery: involvement of potassium channels.
TLDR
The vasodilator activity of adenosine has been associated with selective stimulation of A2 receptors and no elevation in cyclic GMP levels could be observed in tissues stimulated with CPA or DPMA, indicating the A1-selective nature of this agonist. Expand
EEG asymmetry and heart rate during experience of hypnotic analgesia in high and low hypnotizables.
TLDR
During hypnotic analgesia the hemispheric asymmetry found in high hypnotizables was parallel to a significant reduction in the spectral mid-frequency peak of heart period variability which indicated a decrease in the level of sympathetic activity. Expand
Differential pharmacologic sensitivity of cyclic nucleotide phosphodiesterase isozymes isolated from cardiac muscle, arterial and airway smooth muscle.
TLDR
While cardiac and vascular smooth muscle phosphodiesterase isozymes are pharmacologically similar, there is pharmacological and substrate heterogeneity of peak III phosphodiesters in aortic vs. trachea smooth muscle within the same species. Expand
Pharmacological analysis of alpha-2 adrenergic mechanisms in nociception and ataxia.
TLDR
The results indicate that alpha-2 adrenergic agonists can produce antinociception and further suggest that this may be dissociable from the ataxia. Expand
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