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Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons.
Despite high leptin levels, most obese humans and rodents lack responsiveness to its appetite-suppressing effects. We demonstrate that leptin modulates NPY/AgRP and alpha-MSH secretion from the ARH… Expand
Ghrelin mediates stress-induced food-reward behavior in mice.
The popular media and personal anecdotes are rich with examples of stress-induced eating of calorically dense "comfort foods." Such behavioral reactions likely contribute to the increased prevalence… Expand
Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System
- I. Cakir, M. Perello, Omar Lansari, N. Messier, C. Vaslet, E. Nillni
- Biology, Medicine
- PloS one
- 15 December 2009
Sirt1 is an evolutionarily conserved NAD+ dependent deacetylase involved in a wide range of processes including cellular differentiation, apoptosis, as well as metabolism, and aging. In this study,… Expand
Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner
BACKGROUND Ghrelin is a potent orexigenic hormone that likely impacts eating via several mechanisms. Here, we hypothesized that ghrelin can regulate extra homeostatic, hedonic aspects of eating… Expand
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity.
Feeding on high-calorie (HC) diets induces serious metabolic imbalances, including obesity. Understanding the mechanisms against excessive body weight gain is critical for developing effective… Expand
Ghrelin Indirectly Activates Hypophysiotropic CRF Neurons in Rodents
Ghrelin is a stomach-derived hormone that regulates food intake and neuroendocrine function by acting on its receptor, GHSR (Growth Hormone Secretagogue Receptor). Recent evidence indicates that a… Expand
Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing*
- I. Cakir, N. E. Cyr, +4 authors E. Nillni
- Biology, Medicine
- The Journal of Biological Chemistry
- 2 May 2013
Background: The α-MSH peptide is essential in regulating food intake and energy expenditure. Results: ER stress induced by obesity reduces α-MSH, accumulates POMC, and decreases the enzyme PC2.… Expand
Acute High Fat Diet Consumption Activates the Mesolimbic Circuit and Requires Orexin Signaling in a Mouse Model
Overconsumption of palatable energy-dense foods has negative health implications and it is associated with obesity and several eating disorders. Currently, little is known about the neuronal… Expand
Analysis of brain nuclei accessible to ghrelin present in the cerebrospinal fluid
Ghrelin is a stomach-derived peptide hormone that acts in the brain to regulate many important physiological functions. Ghrelin receptor, named the growth hormone secretagogue receptor (GHSR), is… Expand
The Role of Ghrelin in Reward-Based Eating
The peptide hormone ghrelin acts in the central nervous system as a potent orexigenic signal. Not only is ghrelin recognized as playing an important role in feeding circuits traditionally thought of… Expand