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C-reactive protein: a critical update.
In the mid 1990s, immunoassays for C-reactive protein (CRP), with greater sensitivity than those previously in routine use, revealed that increased CRP values, even within the range previouslyExpand
C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease.
BACKGROUND C-reactive protein is an inflammatory marker believed to be of value in the prediction of coronary events. We report data from a large study of C-reactive protein and other circulatingExpand
Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses
Abstract Objective: To assess associations between baseline values of four different circulating markers of inflammation and future risk of coronary heart disease, potential triggers of systemicExpand
Common core structure of amyloid fibrils by synchrotron X-ray diffraction.
Tissue deposition of normally soluble proteins as insoluble amyloid fibrils is associated with serious diseases including the systemic amyloidoses, maturity onset diabetes, Alzheimer's disease andExpand
The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina.
BACKGROUND The pathogenesis of unstable angina is poorly understood, and predicting the prognosis at the time of hospital admission is problematic. Recent evidence suggests that there may be activeExpand
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
Summary Background Associations of C-reactive protein (CRP) concentration with risk of major diseases can best be assessed by long-term prospective follow-up of large numbers of people. We assessedExpand
The physiological structure of human C-reactive protein and its complex with phosphocholine.
BACKGROUND Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury,Expand
Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein.
The acute phase response among plasma proteins is a normal response to tissue injury and is therefore a fundamental aspect of many diverse disease processes. It probably usually has a beneficial netExpand
Particulate air pollution is associated with an acute phase response in men; results from the MONICA-Augsburg Study.
AIMS Episodes of increased air pollution are associated with increases in hospital admissions for cardiovascular disease. Even modest acute phase responses are associated with increased risk ofExpand
C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and
BACKGROUND Inflammatory reactions in coronary plaques play an important role in the pathogenesis of acute atherothrombotic events; inflammation elsewhere is also associated with both atherogenesisExpand