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The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1/USF2 Transcription Factors
TLDR
The results constitute the first functional explanation for an association identified by a GWAS and thereby elucidate a mechanism of thyroid cancer susceptibility and attest to the efficacy of candidate gene approaches in the GWAS era.
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Complications of Thyroid Surgery: Analysis of a Multicentric Study on 14,934 Patients Operated on in Italy over 5 Years
TLDR
Hypoparathyroidism after total thyroidectomy is an important complication that can be successfully treated by therapy, although it is not always easily managed in special circumstances such as in young persons or pregnant women.
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Zuckerkandl's tuberculum: an arrow pointing to the recurrent laryngeal nerve (constant anatomical landmark)
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Identification of the Nonrecurrent Laryngeal Nerve during Thyroid Surgery: 20-Year Experience
TLDR
The results suggest that the best way to avoid morbidity is routine identification of the nerve, which can be done by carefully identifying all the thyroid structures and being suspicious of the presence of the abnormality when the inferior laryngeal nerve is not found in a classic position.
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Preoperative localization and radioguided parathyroid surgery.
Clinical or subclinical hyperparathyroidism is one of the most common endocrine disorders. Excessive secretion of parathyroid hormone is most frequently caused by an adenoma of >or=1 parathyroid…
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Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement
TLDR
Current guidelines do not recommend its routine use in clinical practice, suggesting its usefulness in some cases only, but over the last two decades, nonsurgical, minimally invasive, US-guided techniques have been proposed for the treatment of thyroid nodules.
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Papillary thyroid microcarcinoma (PTMC): prognostic factors, management and outcome in 403 patients.
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MicroRNA profiles in familial and sporadic medullary thyroid carcinoma: preliminary relationships with RET status and outcome.
TLDR
In sMTC and familial MTC, the miR-224 upregulation correlated with the absence of node metastases, lower stages at diagnosis, and with biochemical cure during follow-up, and this dysregulation is probably an early event in C-cell carcinogenesis.
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Natural history, diagnosis, treatment and outcome of medullary thyroid cancer: 37 years experience on 157 patients.
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Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): a mono-institutional 12-year experience
TLDR
The clinical and histopathological records of 149 consecutive patients with papillary thyroid microcarcinoma, homogeneously studied and operated on by the same surgeon in the period 1990 to 2001, were reviewed and no recurrence was observed in patients treated by total thyroidectomy and 131I.
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