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A possible explanation for a neurotoxic effect of the anticancer agent oxaliplatin on neuronal voltage-gated sodium channels.
- F. Grolleau, L. Gamelin, M. Boisdron-Celle, B. Lapied, M. Pelhate, E. Gamelin
- BiologyJournal of neurophysiology
- 1 May 2001
Oxaliplatin, a new widely used anticancer drug, displays frequent, sometimes severe, acute sensory neurotoxicity accompanied by neuromuscular signs that look like the symptoms observed in tetany and…
A scorpion venom neurotoxin paralytic to insects that affects sodium current inactivation: purification, primary structure, and mode of action.
Voltage- and current-clamp studies showed that Lqh alpha IT caused an extreme prolongation of the action potential in both cockroach giant axon and rat skeletal muscle preparations as a result of the slowing and incomplete inactivation of the sodium currents, indicating that it is an alpha toxin which acts on insect sodium channels.
Scorpion Toxins Affecting Sodium Current Inactivation Bind to Distinct Homologous Receptor Sites on Rat Brain and Insect Sodium Channels (*)
- D. Gordon, M. Martin‐Eauclaire, H. Rochat
- Biology, ChemistryThe Journal of Biological Chemistry
- 5 April 1996
The presence of a cluster of receptor sites for scorpion toxins that inhibit sodium current inactivation, which is very similar on insect and rat brain sodium channels, in spite of the structural and pharmacological differences between them is suggested.
The Putative Bioactive Surface of Insect-selective Scorpion Excitatory Neurotoxins*
This work isolated, characterized, and expressed an atypically long excitatory toxin, Bj-xtrIT, whose bioactive features resembled those of classical exciteatory toxins, despite only 49% sequence identity.
Ionic Species Involved in the Electrical Activity of Single Adult Aminergic Neurones Isolated from the Sixth Abdominal Ganglion of the Cockroach Periplaneta Americana
The results suggest that these isolated neurones obtained by dissociation of the dorsal area of the sixth abdominal (A6) ganglion of the cockroach are dorsal unpaired median neurones previously studied in a number of insect species.
Isolation, synthesis and pharmacological characterization of delta-palutoxins IT, novel insecticidal toxins from the spider Paracoelotes luctuosus (Amaurobiidae).
- G. Corzo, P. Escoubas, M. Stankiewicz, M. Pelhate, C. P. Kristensen, T. Nakajima
- BiologyEuropean journal of biochemistry
- 1 September 2000
Four novel insecticidal toxins were isolated from the venom of the spider Paracoelotes luctuosus and named delta-palutoxins IT1 to IT4, which appear to be insect specific and useful both in the development of recombinant baculoviruses in agrochemical applications and also as molecular probes for the investigation of molecular mechanisms of insect selectivity and structure and function of sodium channels.
Functional expression and genetic alteration of an alpha scorpion neurotoxin.
The alpha neurotoxin Lqh alpha IT is toxic to both insects and mammals but exhibits a bioactivity ratio favoring insects (insect/mammal approximately 2). With the objective of increasing this ratio…
NMR structures and activity of a novel alpha-like toxin from the scorpion Leiurus quinquestriatus hebraeus.
Three turn regions involved in the functional binding site of the anti-insect LqhalphaIT toxin reveal significant differences in the Lqh III structure, which affords additional important elements to the definition of the new alpha-like group of scorpion toxins and the mammal versus insect scorpion toxin selectivities.
In vitro folding and functional analysis of an anti-insect selective scorpion depressant neurotoxin produced in Escherichia coli.
Apparently, this efficient bacterial expression system provides the means for studying structure/ activity relationship and the molecular basis for the phylogenetic selectivity of scorpion depressant neurotoxins.
Exploration of the functional site of a scorpion alpha-like toxin by site-directed mutagenesis.
Light is shed on the nature and roles of the residues possibly involved in the biological activity of a scorpion alpha-like toxin and the comparison of BmK M1 with Aah2 and Lqh(alpha)IT showed that the specific orientation of the C-terminus mediated by the reverse turn might be relevant to the preference of alpha-toxin subgroups for phylogenetically distinct yet closely related receptor sites.