• Publications
  • Influence
A possible explanation for a neurotoxic effect of the anticancer agent oxaliplatin on neuronal voltage-gated sodium channels.
Oxaliplatin, a new widely used anticancer drug, displays frequent, sometimes severe, acute sensory neurotoxicity accompanied by neuromuscular signs that look like the symptoms observed in tetany andExpand
  • 290
  • 20
  • PDF
A scorpion venom neurotoxin paralytic to insects that affects sodium current inactivation: purification, primary structure, and mode of action.
A new toxin, Lqh alpha IT, which caused a unique mode of paralysis of blowfly larvae, was purified from the venom of the scorpion Leiurus quinquestriatus hebraeus, and its structural andExpand
  • 156
  • 11
Scorpion Toxins Affecting Sodium Current Inactivation Bind to Distinct Homologous Receptor Sites on Rat Brain and Insect Sodium Channels (*)
Sodium channels posses receptor sites for many neurotoxins, of which several groups were shown to inhibit sodium current inactivation. Receptor sites that bind α- and α-like scorpion toxins are ofExpand
  • 170
  • 7
In vitro folding and functional analysis of an anti-insect selective scorpion depressant neurotoxin produced in Escherichia coli.
The selective toxicity of depressant scorpion neurotoxins to insects is useful in studying insect sodium channel gating and has an applied potential. In order to establish a genetic system enabling aExpand
  • 50
  • 5
The Putative Bioactive Surface of Insect-selective Scorpion Excitatory Neurotoxins*
Scorpion neurotoxins of the excitatory group show total specificity for insects and serve as invaluable probes for insect sodium channels. However, despite their significance and potential forExpand
  • 90
  • 4
Functional expression and genetic alteration of an alpha scorpion neurotoxin.
The alpha neurotoxin Lqh alpha IT is toxic to both insects and mammals but exhibits a bioactivity ratio favoring insects (insect/mammal approximately 2). With the objective of increasing this ratioExpand
  • 90
  • 4
Ionic Species Involved in the Electrical Activity of Single Adult Aminergic Neurones Isolated from the Sixth Abdominal Ganglion of the Cockroach Periplaneta Americana
Adult neurones were obtained by dissociation of the dorsal area of the sixth abdominal (A6) ganglion of the cockroach, and electrical properties were studied with the patch-clamp technique. TheExpand
  • 93
  • 4
  • PDF
NMR structures and activity of a novel alpha-like toxin from the scorpion Leiurus quinquestriatus hebraeus.
NMR structures of a new toxin from the scorpion Leiurus quinquestriatus hebraeus (Lqh III) have been investigated in conjunction with its pharmacological properties. This toxin is proposed to belongExpand
  • 68
  • 4
Exploration of the functional site of a scorpion alpha-like toxin by site-directed mutagenesis.
Scorpion alpha-neurotoxins can be classified into distinct subgroups according to their sequence and pharmacological properties. Using toxicity tests, binding studies, and electrophysiologicalExpand
  • 55
  • 4
  • PDF
Isolation, synthesis and pharmacological characterization of delta-palutoxins IT, novel insecticidal toxins from the spider Paracoelotes luctuosus (Amaurobiidae).
Four novel insecticidal toxins were isolated from the venom of the spider Paracoelotes luctuosus (Araneae: Amaurobiidae) and named delta-palutoxins IT1 to IT4. The four toxins are homologous 36-37Expand
  • 70
  • 4