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Cytotoxic activity of lupane-type triterpenes from Glochidion sphaerogynum and Glochidion eriocarpum two of which induce apoptosis.
Triterpenes 2 - 7 were tested against the growth of three human tumor cell lines, MCF-7, NCI-H-460 and SF-268 and indicated that triterpenes 5 and 6 exerted their antiproliferative activity through the involvement of apoptosis while triterpene 3 did not.
Xanthones as inhibitors of growth of human cancer cell lines and their effects on the proliferation of human lymphocytes in vitro.
Effect of abietane diterpenes from Plectranthus grandidentatus on the growth of human cancer cell lines.
- Cristina Gaspar Marques, M. Pedro, M. F. Simões, M. S. Nascimento, M. Pinto, B. Rodriguez
- Chemistry, BiologyPlanta medica
- 1 September 2002
Five known abietane diterpenes, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone, and coleon U, isolated from Plectranthus grandidentatus Gürke, were evaluated for their in vitro antiproliferative activity against five human cancer cell lines.
Effects of natural prenylated flavones in the phenotypical ER (+) MCF-7 and ER (-) MDA-MB-231 human breast cancer cells.
Modulation of Autophagy by a Thioxanthone Decreases the Viability of Melanoma Cells
(1) Background: Our previous studies unveiled the hit thioxanthone TXA1 as an inhibitor of P-glycoprotein (drug efflux pump) and of human tumor cells growth, namely of melanoma cells. Since TXA1 is…
Hair as an alternative matrix in bioanalysis.
Issues concerning hair structure, collection, storage and analysis are reviewed, and representative examples of drug quantification using hair are summarized, emphasizing its potentialities and limitations as an alternative biological matrix for toxicological analyses.
Catechols from abietic acid synthesis and evaluation as bioactive compounds.
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
- Cláudia Valente, M. Pedro, A. Duarte, M. S. Nascimento, P. Abreu, Maria-José U. Ferreira
- ChemistryJournal of natural products
- 23 April 2004
Diterpenes 1-3 and previously described pubescene D were shown to be moderate inhibitors of the growth of MCF-7, NCI-H460, and SF-268 human tumor cell lines, whereas compounds 2 and 3 also exhibited significant antibacterial activity against Staphylococcus aureus.
Bioactive meroditerpenes and indole alkaloids from the soil fungus Neosartorya fischeri (KUFC 6344), and the marine-derived fungi Neosartorya laciniosa (KUFC 7896) and Neosartorya tsunodae (KUFC 9213)
Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate
It is shown that pre-incubation with butyrate enhanced significantly 3-BP cytotoxicity, especially in the most resistant breast cancer cell line, SK-BR-3, and the potential use ofbutyrate as adjuvant of 3- BP in the treatment of breast cancer resistant cells, namely ER (−).