• Publications
  • Influence
Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation
Human skin-resident IL-10+ regulatory dendritic cells induce T reg cells that suppress allogeneic skin graft inflammation.
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health.
According to the quality of response they mediate, autoreactive T cells recognizing islet beta cell peptides could represent both disease effectors in the development of type 1 diabetes (T1DM) andExpand
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.
Type 1 diabetes is a T-cell-mediated disease that is associated with loss of immunological tolerance to self-antigens. The mechanisms involved in maintenance of peripheral tolerance include aExpand
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.
The final pathway of beta cell destruction leading to insulin deficiency, hyperglycemia, and clinical type 1 diabetes is unknown. Here we show that circulating CTLs can kill beta cells viaExpand
Antigen targets of type 1 diabetes autoimmunity.
  • B. Roep, M. Peakman
  • Biology, Medicine
  • Cold Spring Harbor perspectives in medicine
  • 1 April 2012
Type 1 diabetes is characterized by recognition of one or more β-cell proteins by the immune system. The list of target antigens in this disease is ever increasing and it is conceivable thatExpand
Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4.
During immune responses, antigen-presenting cells (APCs) process antigens and present peptide epitopes complexed with human leukocyte antigen (HLA) molecules. CD4 cells recognize these naturallyExpand
Translational Mini‐Review Series on Type 1 Diabetes:
Systematic analysis of T cell epitopes in autoimmune diabetes
T cell epitopes represent the molecular code words through which the adaptive immune system communicates. In the context of a T cell‐mediated autoimmune disease such as type 1 diabetes, CD4 and CD8 TExpand
Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers
OBJECTIVE Type 1 diabetes results from selective T-cell–mediated destruction of the insulin-producing β-cells in the pancreas. In this process, islet epitope–specific CD8+ T-cells play a pivotalExpand
Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death
OBJECTIVE CD4 T-cells secreting interleukin (IL)-17 are implicated in several human autoimmune diseases, but their role in type 1 diabetes has not been defined. To address the relevance of suchExpand
A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides*
Background: How does a limited pool of <108 T cell receptors (TCRs) provide immunity to >1015 antigens? Results: A single TCR can respond to >one million different decamer peptides. Conclusion: ThisExpand