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Once-daily initiation with biphasic insulin aspart 30 versus insulin glargine in patients with type 2 diabetes inadequately controlled with oral drugs: an open-label, multinational RCT
TLDR
BIAsp 30 fulfilled the statistical criteria for non-inferiority and superiority to insulin glargine and, according to pre-defined criteria, the improvements in HbA1c are considered clinically equivalent.
Elucidation and in planta reconstitution of the parthenolide biosynthetic pathway.
Parthenolide, the main bioactive compound of the medicinal plant feverfew (Tanacetum parthenium), is a promising anti-cancer drug. However, the biosynthetic pathway of parthenolide has not been
Work stress related lipid disorders and arterial hypertension in professional drivers - a cross-sectional study.
TLDR
The study provides the evidence for the significant association of total OSI and underload with lipid disorders and elevated blood pressure in professional drivers, which could be a possible link between job stress and coronary heart disease.
Induced Resistance in the Human Non Small Cell Lung Carcinoma (NCI-H460) Cell Line In Vitro by Anticancer Drugs
TLDR
Gene expression data confirmed the induction of mdr1 (P-gp), as judged by the observed 15-fold increase in its mRNA concentration in doxorubicin-resistant NCI-H460/R cells, which should develop a rationale for a novel treatment of NSCLC with appropriate modulators of resistance aimed at improving the outcome of the acquired drug resistance.
Synergistic effects of the purine analog sulfinosine and curcumin on the multidrug resistant human non-small cell lung carcinoma cell line (NCI-H460/R)
TLDR
The results show that sulfinosine and curcumin overcome MDR in non-small cell lung carcinoma cell line (NSCLC), especially in combination despite the presence of a mutated p53 gene.
Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells.
An extended study of minor diarylheptanoids from the bark of black alder has resulted in the isolation of twenty diarylheptanoids, ten of which have not previously been reported (14-18, 20-24). The
Biphasic insulin aspart 30: Better glycemic control than with premixed human insulin 30 in obese patients with Type 2 diabetes
TLDR
Adding BIAsp30 to met in obese patients with T2DM results in better glycemic control and less weight gain than adding BHI30, and there was no significant difference in the frequency of hypoglycemic episodes between groups.
Hepatitis C virus genotypes and the development of hepatocellular carcinoma
TLDR
Investigation of the prevalence of hepatitis C virus infection in patients with hepatocellular carcinoma in a geographic area to determine if there is a correlation between HCV genotypes and the development of HCC found a link.
Cytotoxic activity of sesquiterpene lactones from Inula britannica on human cancer cell lines
TLDR
Five new sesquiterpene lactones were isolated from Inula britannica collected in the wild from Serbia along with five known compounds and showed similar cytotoxic activity toward drug sensitive and drug resistant cancer cell lines.
Anti-cancer effects of cerium oxide nanoparticles and its intracellular redox activity.
TLDR
Changes in intracellular redox status induced by CONP are partly attributed to the prooxidant activity of the nanoparticles, and low inhibitory potential of CONP in the other human cell lines tested indicates that CONP may be safe for human usage in industry and medicine.
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