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Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro.
- L. Quintieri, Sara Bortolozzo, +5 authors M. Floreani
- Medicine, Chemistry
- Drug metabolism and pharmacokinetics
The aim of this study was to examine in vitro, by means of kinetic analysis and molecular docking simulations, the effects of the flavone diosmetin and its flavanone analog hesperetin on CYP… Expand
Regulation of Serotonin Transport in Human Platelets by Tyrosine Kinase Syk
- M. Pavanetto, Alessandro Zarpellon, Christian Borgo, A. Donella-Deana, R. Deana
- Medicine, Biology
- Cellular Physiology and Biochemistry
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter involved in the regulation of numerous neuro-physiological processes. The circulating level of 5-HT is regulated by the membrane… Expand
Inhibitory effect by new monocyclic 4-alkyliden-beta-lactam compounds on human platelet activation
In the present study some new beta-lactam compounds were screened for their ability to inhibit human platelet activation. In particular four compounds differing in the group on the nitrogen atom of… Expand
Flow Amplifiers in Hydrostatic Steering
Transport of serotonin into human platelets is regulated by tyrosinephosphorylation of SERT and its interaction with integrin-alphaII/beta3