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Melasma: a clinical, light microscopic, ultrastructural, and immunofluorescence study.
Light, histochemical, and electron microscopic studies revealed an increase in number and activity of type-specific melanocytes which appeared to be engaged in increased formation, melanization, and transfer of pigment granules (melanosomes) to the epidermis as well as to the dermis. Expand
Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light.
Abstract Oral administration of a photoactive drug, 8-methoxypsoralen (methoxsalen), followed by exposure to a high-intensity, longwave ultraviolet-light system resulted in complete clearing ofExpand
Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin.
Oral administration of PL is an effective systemic chemophotoprotective agent leading to significant protection of skin against UV radiation. Expand
Beta Carotene Therapy for Erythropoietic Protoporphyria and Other Photosensitivity Diseases
It is concluded that beta carotene is an effective treatment for EPP, but that other forms of photosensitivity will need empirical therapeutic study with this compound to determine the range of effectiveness, if any, of this compound in conditions other than EPP. Expand
Racial Differences in the Fate of Melanosomes in Human Epidermis
P pigment in the skin is located in a very small granule, the melanosome1, which is barely visible in the light microscope, and is transferred into the keratinizing or malpighian cell2. Expand
A clinical trial of the effects of oral beta-carotene on the responses of human skin to solar radiation.
The observed effects were too small to recommend the use of beta-carotene as a photoprotective agent for sunburn, but the methods developed provide a workable model for randomized controlled trials for evaluating the efficacy of systemic photoprotsective agents. Expand
Mechanism of depigmentation by hydroquinone.
Findings indicate that HQ affects not only the formation, melanization, and degradation of melanosomes, but that it affects also the membraneous structures of melanocytes and eventually causes necrosis of whole melanocytes. Expand
Hydroquinone and psoralens in the therapy of hypermelanosis and vitiligo.
A decade of experience indicates that early misgivings that psoralen derivatives might induce serious untoward effects were unjustified and the larger doses advocated by El Mofty in Egypt for the treatment of vitiligo appear to be more effective than the smaller doses generally advocated. Expand
The Presently Known Distribution of Furocoumarins (Psoralens) in Plants
Interest in many ancient drugs and herbal concoctions has been revived because some of these medicaments have been found to contain specific pharmacological agents which exert scientifically recognizable therapeutic effects. Expand
Free radicals in human skin before and after exposure to light.
Human skin exhibited a stable electron spin resonance (ESR) signal before irradiation, only if the samples were pigmented, and radical yields measured in “white” and pigmented skin as a function of ultraviolet exposure dose showed that fewer radicals were generated in pigmentedskin. Expand