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Utilization of Surface Equilibria for Controlling Heterogeneous Nucleation: Making the “Disappeared” Polymorph of 3-Aminobenzensulfonic Acid “Reappear”
The ability to control crystal form is essential for the development of materials with desired properties. The rational design of heterosurfaces to control nucleation is one such approach.Expand
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Oxidized phospholipid content destabilizes the structure of reconstituted high density lipoprotein particles and changes their function.
High density lipoprotein (HDL) particles are made up of lipid and protein constituents and apolipoprotein A-I (apoA-I) is a principal protein component that facilitates various biological activitiesExpand
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The effect of ionotropic gelation residence time on alginate cross-linking and properties.
The ability to engineer biocompatible polymers with controllable properties is highly desirable. One such approach is to cross-link carbohydrate polymers using ionotropic gelation (IG). PreviousExpand
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Impact of Solid-State Form on the Disproportionation of Miconazole Mesylate.
Approximately 50% of solid oral dosage forms utilize salt forms of the active pharmaceutical ingredient (API). A major challenge with the salt form is its tendency to disproportionate to produce theExpand
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The discovery and investigation of a crystalline solid solution of an active pharmaceutical ingredient.
Understanding the phase behavior of crystal forms is essential in drug formulation development, as physical stability of the active pharmaceutical ingredient (API) is critical to achieving theExpand
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Oxidized-phospholipids in reconstituted high density lipoprotein particles affect structure and function of recombinant paraoxonase 1.
Paraoxonase 1 (PON1) is an HDL-associated enzyme and exhibits anti-inflammatory, anti-diabetic, and anti-atherogenic properties. Association of PON1 to HDL particles increases the stability andExpand
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Polymorphism of vanillin revisited: the discovery and selective crystallization of a rare crystal structure
While polymer induced heterogeneous nucleation (PIHn) has been shown to be a powerful tool for crystallization control and polymorph screening the factors influencing PIHn, such as solvent selection,Expand
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Effect of excipient properties, water activity, and water content on the disproportionation of a pharmaceutical salt
Graphical abstract Figure. No Caption available. &NA; Excipients are crucial components of most pharmaceutical formulations. In the case of a solid oral dosage formulation containing the salt form ofExpand
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Predicting the Nucleation Induction Time Based on Preferred Intermolecular Interactions
A key challenge in rationally designing heterogeneous surfaces for controlling crystallization is overcoming the lack of understanding the influence of surface properties has on nucleation. PreviousExpand
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Dispersion of chitin nanocrystals in polylactic acid nanocomposites prepared via liquid assisted extrusion by triethyl citrate
Dispersion of chitin nanocrystals in polylactic acid nanocomposites prepared via liquid assisted extrusion by triethyl citrate