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Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat.
We have shown that osteogenic protein-1 (OP-1) (bone morphogenetic protein-7) is responsible for the induction of nephrogenic mesenchyme during embryonic kidney development. Gene knock-out studiesExpand
Reduction in the expression and action of transforming growth factor beta 1 on lactotropes during estrogen-induced tumorigenesis in the anterior pituitary.
TLDR
The levels of TGF-beta 1 protein and mRNA in anterior pituitary tissues were reduced over time after estrogen treatment during the development of pituitARY tumors, suggesting that estrogen enhanced lactotropic proliferation in anterior Pituitary glands. Expand
Control of transcription initiation in vitro requires binding of a transcription factor to the distal promoter of the ovalbumin gene.
TLDR
It is proposed that a soluble factor activates transcription through binding to the direct repeat of GTCAAA sequence upstream from the ovalbumin gene, which is competed with DNA fragments containing this sequence. Expand
An Upstream Element Containing an ETS Binding Site Is Crucial for Transcription of the Human Presenilin-1 Gene*
TLDR
Transfection and footprinting assays correlate to suggest that Sp1 transcription factor(s) bind at several sites upstream and downstream from the initiation site and activate the transcription of the PS1 promoter, suggesting that protein-protein interactions between factors recognizing downstream and upstream sequences are involved. Expand
Opposing Actions of Two Transforming Growth Factor-β Isoforms on Pituitary Lactotropic Cell Proliferation.
TLDR
Determinations of TGFβ3 actions in vitro in primary cultures of pituitary cells indicated that TGF β3 concentration dependently increases lactotropic cell proliferation. Expand
Regulation of Transcription of the Human Presenilin-1 Gene by Ets Transcription Factors and the p53 Protooncogene*
TLDR
It is shown here that p53 also suppresses the transcription of a presenilin-1 promoter-chloramphenicol acetyltransferase reporter synthetic gene in transient infection assays in neuroblastoma (SK-N-SH) and hepatoma (HepG2) cell lines. Expand
Comparison of the Effects of Alcohol and Acetaldehyde on Proopiomelanocortin mRNA Levels and β-Endorphin Secretion from Hypothalamic Neurons in Primary Cultures
TLDR
The close association between the ethanol-induced IR-beta-EP secretion and ethanol-regulated POMC mRNA expression suggests that ethanol regulates both secretion and production of beta-EP peptide in the hypothalamic neurons. Expand
Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter.
TLDR
It is shown that in vitro translated ER81 indeed binds specifically to the -10 region of the PS1 promoter and that ER81 activates by two- to threefold the basal transcription of a presenilin-1 promoter-chloramphenicol acetyltransferase reporter synthetic gene (-119, +178)PS1CAT in transient infection assays in neuroblastoma cells (SK-N-SH). Expand
Cyclic AMP and ethanol interact to control apoptosis and differentiation in hypothalamic beta-endorphin neurons.
TLDR
The results suggest that ethanol neurotoxicity onbeta-EP neurons during early neuronal differentiation involves an apoptotic process and that the cAMP signaling system plays an important role in controlling apoptosis and differentiation of the beta-EP neuronal system. Expand
Opposing actions of two transforming growth factor-beta isoforms on pituitary lactotropic cell proliferation.
TLDR
Determinations of TGFbeta3 actions in vitro in primary cultures of pituitary cells indicated that TGF Beta3 concentration dependently increases lactotropic cell proliferation, and data indicate that unlike many other tissues, TGF beta1 and TGFBeta3 have opposite actions on lactotropic proliferation in the pituitaries. Expand
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