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Nucleoside transporter proteins.
TLDR
Nucleoside transporters can play physiological roles other than salvages, such as the modulation of extracellular and intracellular adenosine concentrations, and several polymorphisms have been described in CNT and ENT proteins that could affect nucleoside homeostasis,Adenosine signalling events or nucleosid-derived drug cytotoxicity or pharmacokinetics. Expand
Regulatory and molecular aspects of mammalian amino acid transport.
Extracellular adenosine activates AMP-dependent protein kinase (AMPK)
TLDR
It is shown that adenosine, when added at physiological concentrations, activates AMPK and promotes ACC phosphorylation, and nucleoside transporters might be novel players in the complex regulation of AM PK and energy metabolism. Expand
Expression of the nucleoside‐derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors
TLDR
HCNT1 was by far the isoform whose expression was most frequently reduced or lost in the 3 types of gynecologic tumors analyzed, and this study anticipates high variability in drug uptake efficiency in solid tumors. Expand
Role of CNT3 in the transepithelial flux of nucleosides and nucleoside‐derived drugs
TLDR
A critical role is underline in the renal reabsorption of nucleosides and their derivatives as well as in their intracellular metabolism in renal epithelial cell lines. Expand
Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity.
TLDR
Human pancreatic adenocarcinoma cells overexpress hENT1, although they retain the ability to express a functional hCNT1 transporter, an isoform that confers sensitivity to gemcitabine. Expand
In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta.
To better understand the role of human equilibrative (hENTs) and concentrative (hCNTs) nucleoside transporters in physiology and pharmacology, we investigated the regional, cellular, and spatialExpand
Nucleoside transporters in chronic lymphocytic leukaemia
TLDR
Sensitivity of CLL cells to fludarabine has also been recently correlated with ENT-type transport function, suggesting that, besides the integrity of apoptotic pathways and appropriate intracellular metabolism, transport across the plasma membrane is also a relevant event during CLL treatment. Expand
Transport of Lamivudine [(-)-β-l-2′,3′-Dideoxy-3′-thiacytidine] and High-Affinity Interaction of Nucleoside Reverse Transcriptase Inhibitors with Human Organic Cation Transporters 1, 2, and 3
TLDR
Data reveal that NRTIs experience a high-affinity interaction with hOCTs, suggesting a putative role for these drugs as modulators of hO CT activity, and 3TC is a novel substrate for hOcts and the inhibition of its uptake at low concentrations of ABC and AZT could have implications for the pharmacokinetics of 3TC. Expand
Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes.
TLDR
The hepatic activity of hENT1 and hCNT1/2 transporters will determine the in vivo hepatic distribution and therefore the efficacy and/or toxicity of nucleoside drugs used to treat hepatic diseases. Expand
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