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A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer.
Growth-related oncogene (GRO), a member of the CXC chemokine subfamily, plays a major role in inflammation and wound healing. CXC chemokines have been found to be associated with tumorigenesis,… Expand
The T‐box transcription factor Tbx2: Its role in development and possible implication in cancer
Tbx2 is a member of the T‐box family of transcription factors that are crucial in embryonic development. Recent studies suggest that T‐box factors may also play a role in controlling cell cycle… Expand
Gene-environment interaction: the role of SULT1A1 and CYP3A5 polymorphisms as risk modifiers for squamous cell carcinoma of the oesophagus.
An imbalance in the activities of enzymes involved in the metabolism, conjugation and transport of xenobiotics may account for the variability in susceptibility to the development of complex diseases… Expand
MicroRNA Polymorphisms and Environmental Smoke Exposure as Risk Factors for Oesophageal Squamous Cell Carcinoma
- Y. Wang, M. Vogelsang, Georgia Schäfer, M. Matejcic, M. Parker
- Biology, Medicine
- PloS one
- 21 October 2013
MicroRNAs (miRNAs) and related polymorphisms have been implicated in the susceptibility to oesophageal squamous cell carcinoma (OSCC). In our study, three miRNA-related SNPs: rs6505162 A>C (pre-miRNA… Expand
The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer
BackgroundThe Glutathione S-transferases (GSTs) comprise a group of enzymes that are critical in the detoxification of carcinogens. In this study the effects of polymorphisms in these genes on the… Expand
The receptor tyrosine kinase Axl in cancer: Biological functions and therapeutic implications
- J. D. Paccez, M. Vogelsang, M. Parker, L. Zerbini
- International journal of cancer
- 1 March 2014
The receptor tyrosine kinase Axl has been implicated in the malignancy of different types of cancer. Emerging evidence of Axl upregulation in numerous cancers, as well as reports demonstrating that… Expand
Distinct genetic association at the PLCE1 locus with oesophageal squamous cell carcinoma in the South African population.
Oesophageal squamous cell carcinoma (OSCC) has a high prevalence in the Black and Mixed Ancestry populations of South Africa. Recently, three genome-wide association studies in Chinese populations… Expand
CYP3A5 genotypes and risk of oesophageal cancer in two South African populations.
CYP3A5 is the major cytochrome P450 enzyme in the oesophagus and metabolises many potentially carcinogenic compounds. The frequencies of CYP3A5 allelic variants, CYP3A5*2, *3, *6 and *7 which code… Expand
Breast tumour cell-induced down-regulation of type I collagen mRNA in fibroblasts
SummaryThis study investigated the modulation of type I collagen gene expression in normal fibroblasts by breast tumour cells. Northern analysis of total RNA extracted from stages I, II and III… Expand