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N6-methyladenosine-dependent regulation of messenger RNA stability
The results indicate that the dynamic mA modification is recognized by selectively binding proteins to affect the translation status and lifetime of mRNA and controls RNA decay in a methylation-dependent manner.
The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data
It is shown how pipelining two computer algorithms based on nucleotide cyclic motifs, MC-Fold and MC-Sym, reproduces a series of experimentally determined RNA three-dimensional structures from the sequence, demonstrating how crucial the consideration of all base-pairing interactions is in filling the gap between sequence and structure.
Global Pyrogeography: the Current and Future Distribution of Wildfire
A multivariate quantification of environmental drivers for the observed, current distribution of vegetation fires using statistical models of the relationship between fire activity and resources to burn, climate conditions, human influence, and lightning flash rates at a coarse spatiotemporal resolution is presented.
m6A-dependent regulation of messenger RNA stability
It is shown that m6A is selectively recognized by the human YTH domain family 2 (YTHDF2) ‘reader’ protein to regulate mRNA degradation and established the role of YTH DF2 in RNA metabolism, showing that binding of Y THDF2 results in the localization of bound mRNA from the translatable pool to mRNA decay sites, such as processing bodies.
Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA.
A method that accurately determines m(6)A status at any site in mRNA/lncRNA, termed site-specific cleavage and radioactive-labeling followed by ligation-assisted extraction and thin-layer chromatography (SCARLET), which determines the precise location of the m( 6)A residue and its modification fraction, which are crucial parameters in probing the cellular dynamics of m(7)A modification.
Climate change and disruptions to global fire activity
Future disruptions to fire activity will threaten ecosystems and human well-being throughout the world, yet there are few fire projections at global scales and almost none from a broad range of
N6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions
It is found that m6A alters the local structure in mRNA and long non-coding RNA (lncRNA) to facilitate binding of heterogeneous nuclear ribonucleoprotein C (HNRNPC), an abundant nuclear RNA-binding protein responsible for pre-mRNA processing.
Environmental controls on the distribution of wildfire at multiple spatial scales
Despite its widespread occurrence globally, wildfire preferentially occupies an environmental middle ground and is significantly less prevalent in biomes characterized by environmental extremes
Staufen1 regulates diverse classes of mammalian transcripts
It is demonstrated that Stau1 binds to a complex structure within the ARF1 3′‐UTR, and the efficiency of SMD increases during the differentiation of C2C12 myoblasts to myotubes, and proposed thatStau1 influences the expression of a wide variety of physiologic transcripts and metabolic pathways.
N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein
The results show that m6A-dependent RNA structural alterations can promote direct binding of m 6A-modified RNAs to low-complexity regions in RNA binding proteins.