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The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data
The classical RNA secondary structure model considers A·U and G·C Watson–Crick as well as G·U wobble base pairs. Here we substitute it for a new one, in which sets of nucleotide cyclic motifs defineExpand
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m6A-dependent regulation of messenger RNA stability
N6-methyladenosine (m6A) is the most prevalent internal (non-cap) modification present in the messenger RNA of all higher eukaryotes. Although essential to cell viability and development, the exactExpand
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Global Pyrogeography: the Current and Future Distribution of Wildfire
Climate change is expected to alter the geographic distribution of wildfire, a complex abiotic process that responds to a variety of spatial and environmental gradients. How future climate change mayExpand
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Climate change and disruptions to global fire activity
Future disruptions to fire activity will threaten ecosystems and human well-being throughout the world, yet there are few fire projections at global scales and almost none from a broad range ofExpand
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Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA.
N(6)-methyladenosine (m(6)A) is the most abundant modification in mammalian mRNA and long noncoding RNA (lncRNA). Recent discoveries of two m(6)A demethylases and cell-type and cell-state-dependentExpand
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N6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions
RNA-binding proteins control many aspects of cellular biology through binding single-stranded RNA binding motifs (RBMs). However, RBMs can be buried within their local RNA structures, thus inhibitingExpand
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Staufen1 regulates diverse classes of mammalian transcripts
It is currently unknown how extensively the double‐stranded RNA‐binding protein Staufen (Stau)1 is utilized by mammalian cells to regulate gene expression. To date, Stau1 binding to theExpand
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N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein
Abstract N 6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNA (mRNA), and affects almost every stage of the mRNA life cycle. The YTH-domain proteins canExpand
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Environmental controls on the distribution of wildfire at multiple spatial scales
Despite its widespread occurrence globally, wildfire preferentially occupies an environmental middle ground and is significantly less prevalent in biomes characterized by environmental extremesExpand
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Genome-wide Identification and Quantitative Analysis of Cleaved tRNA Fragments Induced by Cellular Stress*
Background: Regulation of stress-induced tRNA cleavage by angiogenin is not well studied. Results: tRNA fragment accumulation was higher during oxidative than hypertonic stress. Conclusion: tRNAExpand
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