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Synaptic, transcriptional, and chromatin genes disrupted in autism
Using exome sequencing, it is shown that analysis of rare coding variation in 3,871 autism cases and 9,937 ancestry-matched or parental controls implicates 22 autosomal genes at a false discovery rate of < 0.05, plus a set of 107 genes strongly enriched for those likely to affect risk (FDR < 0.30).
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism
Cannabis use in children and adolescents with first episode psychosis: Influence on psychopathology and short-term outcome (CAFEPS study)
Efficacy and safety of second-generation antipsychotics in children and adolescents with psychotic and bipolar spectrum disorders: Comprehensive review of prospective head-to-head and…
Metabolic and hormonal side effects in children and adolescents treated with second-generation antipsychotics.
- D. Fraguas, J. Merchán-Naranjo, C. Arango
- Medicine, PsychologyThe Journal of clinical psychiatry
- 31 July 2008
Metabolic and hormonal side effects of SGAs in children and adolescents should be carefully monitored when prescribing these drugs.
Antipsychotics in children and adolescents: Increasing use, evidence for efficacy and safety concerns
Olanzapine compared to quetiapine in adolescents with a first psychotic episode
- C. Arango, O. Robles, D. Moreno
- Psychology, MedicineEuropean Child & Adolescent Psychiatry
- 5 February 2009
Olanzapine and quetiapine reduced psychotic symptoms in this adolescent sample and side effects with both drugs seemed to be more prevalent than those reported in adult studies.
AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders
The results show that de-novo variants in GRIA2 can cause neurodevelopmental disorders, complementing evidence that other genetic causes of ID, ASD and DEE also disrupt glutamatergic synaptic transmission.
The Human Cerebral Cortex Flattens during Adolescence
It is found that the cortical surface flattens during adolescence, and was strongest in the frontal and occipital cortices, in which significant sulcal widening and decreased sulcal depth co-occurred.
Trait and state attributes of insight in first episodes of early-onset schizophrenia and other psychoses: a 2-year longitudinal study.
Insight is a complex phenomenon that depends both on severity of psychopathology and also on disease and subject characteristics, such as past adjustment, IQ, DUP, cognitive functioning, frontal and parietal GM volumes, and age, gender, and ethnicity.