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Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging
The presence of amyloid‐β (Aβ) plaques in the brain is a hallmark pathological feature of Alzheimer's disease (AD). Transgenic mice overexpressing mutant amyloid precursor protein (APP), or bothExpand
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Statin therapy for Alzheimer's disease: will it work?
Disease-modifying therapies are being developed for Alzheimer's disease (AD). These are expected to slow the clinical progression of the disease or delay its onset. Cerebral accumulation of amyloidExpand
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Oral administration of human or murine interferon alpha suppresses relapses and modifies adoptive transfer in experimental autoimmune encephalomyelitis
Chronic relapsing experimental autoimmune encephalitis (CR-EAE) is an inflammatory process of the central nervous system (CNS) that closely resembles the human disease multiple sclerosis (MS). EAEExpand
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Responsible, Safe, and Effective Use of Biologics in the Management of Low Back Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines.
BACKGROUND Regenerative medicine is a medical subspecialty that seeks to recruit and enhance the body's own inherent healing armamentarium in the treatment of patient pathology. This therapy'sExpand
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Oxygen free radicals as inducers of heat shock protein synthesis in cultured human neuroblastoma cells: Relevance to neurodegenerative disease
  • R. Omar, M. Pappolla
  • Chemistry, Medicine
  • European Archives of Psychiatry and Clinical…
  • 1 April 1993
SummaryWe studied heat shock protein (HSP) synthesis by cultured human neuroblastoma cells in response to either hyperthermia or high levels of superoxide anion (oxygen free radical). Both treatmentExpand
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Inhibition of Alzheimer b-Fibrillogenesis by Melatonin *
It is generally postulated that the amyloid b protein (Ab) plays a central role in the progressive neurodegeneration observed in Alzheimer’s disease. Important pathologic properties of this protein,Expand
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Carbon disulfide axonopathy. Another experimental model characterized by acceleration of neurofilament transport and distinct changes of axonal size
The role of axonal transport in the development of structural changes of axons can be examined using experimental models. Two different compounds, 2,5-hexanedione (2,5-HD) and carbon disulfide (CS2),Expand
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Acid phosphatase activity in senile plaques and cerebrospinal fluid of patients with Alzheimer's disease.
The origin of the various components of senile plaques in Alzheimer's disease (AD) continues to be a focus of intense research scrutiny. Lysosomal enzyme activity within the plaques is of particularExpand
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α-spectrins are major ubiquitinated proteins in rat hippocampal neurons and components of ubiquitinated inclusions in neurodegenerative disorders
We have demonstrated that alpha-spectrins (alphaSpISigma* and alphaSpIISigma1) are major ubiquitinated proteins in terminally differentiated hippocampal neurons in culture. Western blottingExpand
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Reinduction of experimental autoimmune encephalomyelitis in mice.
Experimental autoimmune encephalomyelitis (EAE) in Lewis rats and some strains of mice is typically a monophasic disease, and recovered animals are resistant to reinduction of disease. We demonstrateExpand
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