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Wild‐type but not mutant androgen receptor inhibits expression of the hTERT telomerase subunit: a novel role of AR mutation for prostate cancer development
Androgens play a central role in prostate development and prostate cancer proliferation. Induction of telomerase is an early event in prostate carcino‐genesis and is considered as a marker for bothExpand
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The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis
Oncogenic stimuli trigger the DNA damage response (DDR) and induction of the alternative reading frame (ARF) tumor suppressor, both of which can activate the p53 pathway and provide intrinsicExpand
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Characterization of β‐adrenoceptor mediated smooth muscle relaxation and the detection of mRNA for β1‐, β2‐ and β3‐adrenoceptors in rat ileum
Functional and molecular approaches were used to characterize the β‐AR subtypes mediating relaxation of rat ileal smooth muscle. In functional studies, (−)‐isoprenaline relaxation was unchanged byExpand
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Alternative splicing generates two isoforms of the β3‐adrenoceptor which are differentially expressed in mouse tissues
The β3‐adrenoceptor (AR) differs from the β1‐AR and β2‐ARs in having introns within and downstream of the coding block. This study demonstrates two splice variants of the mouse β3‐AR which differExpand
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Characterization of beta-adrenoceptor mediated smooth muscle relaxation and the detection of mRNA for beta1-, beta2- and beta3-adrenoceptors in rat ileum.
1. Functional and molecular approaches were used to characterize the beta-AR subtypes mediating relaxation of rat ileal smooth muscle. 2. In functional studies, (-)-isoprenaline relaxation wasExpand
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Expression of β3‐adrenoceptor mRNA in rat tissues
1 This study examines the expression of β3‐adrenoceptor messenger RNA (β3‐AR mRNA) in rat tissues to allow comparison with atypical β‐adrenoceptors determined by functional and radioligand bindingExpand
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Agonist–antagonist induced coactivator and corepressor interplay on the human androgen receptor
The human androgen receptor (AR) is a member of the nuclear hormone receptor superfamily. However, in contrast to other members of this family the amino-(N)-terminus of AR harbors the majorExpand
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Expression of beta 3-adrenoceptor mRNA in rat brain.
The reverse transcription/polymerase chain reaction was used to demonstrate beta 3-adrenoceptor mRNA in rat brain regions. Levels were highest in hippocampus, cerebral cortex and striatum and lowerExpand
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The coregulator Alien
Alien has characteristics of a corepressor for selected members of the nuclear hormone receptor (NHR) superfamily and also for transcription factors involved in cell cycle regulation and DNA repair.Expand
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The tumor suppressors p33ING1 and p33ING2 interact with alien in vivo and enhance alien-mediated gene silencing.
The tumor suppressor p33ING1 is involved in DNA repair and cell cycle regulation. Furthermore, p33ING1 is a transcriptional silencer that recognizes the histone mark for trimethylated lysine 4 atExpand
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