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Long-term ouabain administration produces hypertension in rats.
Ouabain has recently been identified as an endogenous Na(+)-K+ pump inhibitor. We administered ouabain chronically to normotensive rats with varying degrees of reduced renal mass (RRM) and to normal… Expand
Altered activity of the sodium-potassium pump in arteries of rats with steroid hypertension.
1. Ouabain-sensitive uptake of 86Rb, a measure of the Na+-K+ pump activity, was studied in tail arteries of rats made hypertensive with deoxycorticosterone and saline. 2. Decreased activity of the… Expand
Periventricular forebrain mechanisms for blood pressure regulation.
Periventricular forebrain regions participate in body fluid and cardiovascular regulatory mechanisms that are intimately related to neural participation in experimental hypertension. Ablation of… Expand
Effects of Three Sodium‐Potassium Adenosine Triphosphatase Inhibitors
Reports from several laboratories suggest the presence of an ouabainlike compound in plasma and various animal tissues, particularly during acute volume expansion and in low-renin hypertension. It… Expand
Depressed Function of a Ouabain‐Sensitive Sodium‐Potassium Pump in Blood Vessels from Renal Hypertensive Dogs
- H. Overbeck, M. Pamnani, T. Akera, Theodore M. Brody, F. Haddy
- Circulation research
- 1 June 1976
Vasodilator responses to acute intra-arterial infusions of K+ are attenuated in dogs with chronic one-kidney perinephritic hypertension in rats with chronic two-kidney Goldblatt hypertension, and in… Expand
Humoral factors and the sodium-potassium pump in volume expanded hypertension.
Abstract Bioassay studies in the old and recent literature suggest the presence of an unknown slowly acting pressor agent in the blood of animals and man with volume expanded (low renin)… Expand
Effects of canrenone on blood pressure in rats with reduced renal mass.
- M. Pamnani, W. V. Whitehorn, D. Clough, F. Haddy
- American journal of hypertension
- 1 March 1990
Canrenone, a metabolic product of spironolactone, which competes with ouabain for binding to Na-K-ATPase at the digitalis receptor site and by itself inhibits Na-K-ATPase, was administered… Expand
Vascular sodium-potassium pump activity in various models of experimental hypertension.
1. Ouabain-sensitive 86Rb uptake was used to assess sodium-potassium pump activity in vascular smooth muscle of animals with various types of experimental hypertension. 2. The findings suggest that… Expand
Humoral Na+-K+ pump inhibitory activity in essential hypertension and in normotensive subjects after acute volume expansion.
Plasma from black male patients with essential hypertension was bioassayed for vascular Na+-K+ pump inhibitory activity. Halves of the same rat tail artery were incubated for two hours in boiled… Expand
The Vascular Na+-K+ Pump in Low Renin Hypertension
In this article, we emphasize our studies on animals and humans and those in the literature on humans that bear on the possible role of a circulating Na+-K+ pump inhibitor in the mechanism of… Expand