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Long-term ouabain administration produces hypertension in rats.
Ouabain has recently been identified as an endogenous Na(+)-K+ pump inhibitor. We administered ouabain chronically to normotensive rats with varying degrees of reduced renal mass (RRM) and to normalExpand
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Altered activity of the sodium-potassium pump in arteries of rats with steroid hypertension.
1. Ouabain-sensitive uptake of 86Rb, a measure of the Na+-K+ pump activity, was studied in tail arteries of rats made hypertensive with deoxycorticosterone and saline. 2. Decreased activity of theExpand
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Periventricular forebrain mechanisms for blood pressure regulation.
Periventricular forebrain regions participate in body fluid and cardiovascular regulatory mechanisms that are intimately related to neural participation in experimental hypertension. Ablation ofExpand
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Effects of Three Sodium‐Potassium Adenosine Triphosphatase Inhibitors
Reports from several laboratories suggest the presence of an ouabainlike compound in plasma and various animal tissues, particularly during acute volume expansion and in low-renin hypertension. ItExpand
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Depressed Function of a Ouabain‐Sensitive Sodium‐Potassium Pump in Blood Vessels from Renal Hypertensive Dogs
Vasodilator responses to acute intra-arterial infusions of K+ are attenuated in dogs with chronic one-kidney perinephritic hypertension in rats with chronic two-kidney Goldblatt hypertension, and inExpand
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Humoral factors and the sodium-potassium pump in volume expanded hypertension.
Abstract Bioassay studies in the old and recent literature suggest the presence of an unknown slowly acting pressor agent in the blood of animals and man with volume expanded (low renin)Expand
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Effects of canrenone on blood pressure in rats with reduced renal mass.
Canrenone, a metabolic product of spironolactone, which competes with ouabain for binding to Na-K-ATPase at the digitalis receptor site and by itself inhibits Na-K-ATPase, was administeredExpand
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Vascular sodium-potassium pump activity in various models of experimental hypertension.
1. Ouabain-sensitive 86Rb uptake was used to assess sodium-potassium pump activity in vascular smooth muscle of animals with various types of experimental hypertension. 2. The findings suggest thatExpand
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Humoral Na+-K+ pump inhibitory activity in essential hypertension and in normotensive subjects after acute volume expansion.
Plasma from black male patients with essential hypertension was bioassayed for vascular Na+-K+ pump inhibitory activity. Halves of the same rat tail artery were incubated for two hours in boiledExpand
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The Vascular Na+-K+ Pump in Low Renin Hypertension
In this article, we emphasize our studies on animals and humans and those in the literature on humans that bear on the possible role of a circulating Na+-K+ pump inhibitor in the mechanism ofExpand
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