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(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms.
- F. Lang, C. Böhmer, M. Palmada, G. Seebohm, N. Strutz‐Seebohm, V. Vallon
- BiologyPhysiological reviews
- 1 October 2006
The serum- and glucocorticoid-inducible kinase-1 (SGK1) is ubiquitously expressed and under genomic control by cell stress and hormones, and may play an active role in a multitude of pathophysiological conditions.
Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs
Lowering ceramide abundance may be a central goal for the future development of antidepressants as the role of the acid sphingomyelinase-ceramide system as a target for antidepressants is investigated.
Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1, SGK3, and PKB.
Overactivity of SGK1 may lead not only to excessive ENaC activity and hypertension but also to enhanced SGLT1 activity and obesity.
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation
The results indicate that whereas c-jun is required for apoptosis in sympathetic neurons on NGF withdrawal, an alternate signaling pathway must be induced on p75 activation, and cycloheximide treatment prevented BDNF-mediated apoptosis.
Role and regulation of the serum- and glucocorticoid-regulated kinase 1 in fertile and infertile human endometrium.
The observation that SGK1 targets FOXO1 in differentiating human endometrium, together with its distinct temporal and spatial expression pattern and increased expression in infertile patients, suggest a major role for this kinase in early pregnancy events.
Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases.
ClC-Ka/barttin channels are regulated by SGK1 and SGK3, which may participate in the regulation of transport in kidney and inner ear and be down-regulated by Nedd4-2.
Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4‐2 and the serum and glucocorticoid‐inducible kinase isoforms SGK1/3 and protein kinase B
A powerful novel mechanism that regulates the activity of EAAT1 is revealed, which might participate in the regulation of neuronal excitability and glutamate transport in other tissues.
Post‐translational regulation of EAAT2 function by co‐expressed ubiquitin ligase Nedd4‐2 is impacted by SGK kinases
- C. Boehmer, M. Palmada, Jeyaganesh Rajamanickam, R. Schniepp, S. Amara, F. Lang
- BiologyJournal of neurochemistry
- 1 May 2006
All three SGK isoforms and the related kinase, protein kinase B (PKB), increase EAAT2 activity and plasma membrane expression and thus, may participate in the regulation of neuroexcitability.
Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4.
Cloning, Heterologous Expression, and Characterization of Three Aquaglyceroporins from Trypanosoma brucei*
TbAQPs represent mainly water/glycerol/dihydroxyacetone channels involved in osmoregulation and glycerol metabolism in T. brucei, and may be pivotal for the survival of the parasite survival under non-aerobic or osmotic stress conditions.