• Publications
  • Influence
Heterochromatic Silencing and HP1 Localization in Drosophila Are Dependent on the RNAi Machinery
TLDR
It is demonstrated that this silencing is dependent on the RNA interference machinery, using tandem mini-white arrays and white transgenes in heterochromatin to show loss of silencing as a result of mutations in piwi, aubergine, or spindle-E (homeless), which encode RNAi components.
Role of the male specific lethal (msl) genes in modifying the effects of sex chromosomal dosage in Drosophila.
TLDR
It is suggested that sequestration of the MSL proteins occurs in males to nullify on the autosomes and maintain on the X, an inverse effect produced by negatively acting dosage-dependent regulatory genes as a consequence of the evolution of the X/Y sex chromosomal system.
Plant HDAC inhibitor chrysin arrest cell growth and induce p21WAF1 by altering chromatin of STAT response element in A375 cells
TLDR
The results support an unexpected action of chrysin on the chromatin organization of p21WAF1 promoter through histone methylation and hyper-acetylation and proposes previously unknown sequence specific chromatin modulations in the STAT responsive elements for regulating cell cycle progression negatively.
Dosage Dependent Gene Regulation and the Compensation of the X Chromosome in Drosophila Males
TLDR
Evidence is described for a model that dosage compensation is caused by an 'inverse dosage effect’ that results from an altered stoichiometry of transcriptional regulators on the X versus the autosomes that causes a two-fold increase in target gene expression throughout the genome.
...
1
2
3
4
5
...