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Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment
The effects of antidepressants were augmented following chronic administration for 14 days, especially when given at low doses, suggesting that modifications of the FST can be used to examine the onset of action of antidepressant agents produced by long-term administration.
Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test
Depletion of serotonin prevented the behavioral effects of the selective serotonin reuptake inhibitor fluoxetine in the rat FST, and depletion of serotonin had no impact on the behavior effects induced by the selective norepinephrine reptake inhibitor, desipramine.
Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors.
- J. Cryan, O. O’Leary, I. Lucki
- Psychology, BiologyProceedings of the National Academy of Sciences…
- 25 May 2004
Restoration of NE by using L-threo-3,4-dihydroxyphenylserine reinstated the behavioral effects of both desipramine and paroxetine in Dbh(-/-) mice, thus demonstrating that the reduced sensitivity to antidepressants is related to NE function, as opposed to developmental abnormalities resulting from chronic NE deficiency.
Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice.
- A. J. Mayorga, A. Dalvi, M. Page, S. Zimov-Levinson, R. Hen, I. Lucki
- Biology, PsychologyThe Journal of pharmacology and experimental…
- 1 September 2001
The results suggest that 5-HT(1A) and 5- HT(1B) receptors have different roles in the modulation of the response to antidepressant drugs in the TST, suggesting mediation by enhanced catecholamine function.
Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test.
Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test
- O. O’Leary, Anita J. Bechtholt, J. Crowley, T. E. Hill, M. Page, I. Lucki
- Psychology, BiologyPsychopharmacology
- 21 February 2007
It is demonstrated that endogenous 5-HT synthesis mediates the behavioral effects of SSRIs, but not NRIs, in the TST, whereas disruption of the behavioraleffects of NRI and SSRI antidepressants required disruption of both catecholamine synthesis and vesicular storage and release mechanisms.
Activation of noradrenergic locus coeruleus neurons by hemodynamic stress is due to local release of corticotropin-releasing factor
Corticotropin-releasing factor innervation of the locus coeruleus region: Distribution of fibers and sources of input
Systemic administration of WIN 55,212-2 increases norepinephrine release in the rat frontal cortex
Discrete local application of corticotropin‐releasing factor increases locus coeruleus discharge and extracellular norepinephrine in rat hippocampus
It is demonstrated that CRF applied directly into the LC increases both the activity of LC‐NE neurons and the release of NE in an LC terminal region, the first report to demonstrate a dose‐dependent increase in extracellular NE levels evoked by intra‐LC infusion of CRF in unanesthetized animals.