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Pathogenic Germline Variants in 10,389 Adult Cancers
The largest investigation of predisposition variants in cancer to date finds 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 cancer types, informing future guidelines of variant classification and germline genetic testing in cancer. Expand
Decaying Mouse Volatiles Perceived by Calliphora vicina Rob.‐Desv.
Electroantennographic experiments with female Calliphora vicina antennae led to the identification of dimethyl trisulfide, dimethyl disulfide and nonanal as core volatiles for cadaver detection or postmortem time determination and their correlation to the stages of decay and the accumulated degree days are discussed. Expand
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
It is shown that although point mutations and structural variants that drive cancer are less frequent in non-coding genes and regulatory sequences than in protein-c coding genes, additional examples of these drivers will be found as more cancer genomes become available. Expand
ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins
Interpretation of genetic variation is needed for deciphering genotype-phenotype associations, mechanisms of inherited disease, and cancer driver mutations, and ActiveDriverDB is a comprehensive human proteo-genomics database that annotates disease mutations and population variants through the lens of PTMs. Expand
Pan-cancer analysis of whole genomes
The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies. Expand
Protein-peptide molecular docking with large-scale conformational changes: the p53-MDM2 interaction
The presented case study demonstrates that CABS-dock methodology opens up new opportunities for protein-peptide docking with large-scale changes of the protein receptor structure, as well as obtaining near-native models of the p53-MDM2 complex. Expand
Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites
This study used phosphotyrosine antibody-based immunoaffinity purification in large-scale label-free quantitative phosphoproteomics to identify novel candidate substrates of SRMS, which suggests the involvement of the kinase in a vast array of unexplored cellular functions. Expand
Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
The Cancer LncRNA Census (CLC) is presented, a manually curated dataset of 122 long noncoding RNAs (lncRNAs) with experimentally-validated functions in cancer based on data from the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. Expand
Combined burden and functional impact tests for cancer driver discovery using DriverPower
Testing across a collection of 2583 cancer genomes from the PCAWG project, DriverPower identifies 217 coding and 95 non-coding driver candidates and has the highest F1 score for both coding and non-Coding driver discovery, demonstrating that DriverPower is an effective framework for computational driver discovery. Expand
The olfaction of a fire beetle leads to new concepts for early fire warning systems
Abstract The European fire beetle Melanophila cuspidata oviposits on stems damaged by fire to provide its xylophagous larvae with nutrition. We investigated the beetle's ability to estimate theExpand