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Short-term Effects of Overnight Orthokeratology on Corneal Cell Morphology and Corneal Thickness
TLDR
Findings suggest that the corneal epithelium is the principal structure affected by the mechanical forces exerted by the OK lenses, and responds to OK wear by undergoing significant epithelial cell shape and size alterations with no effects on the cells of the corNEal endothelium or theCorneal stroma. Expand
Insulin‐like growth factor I is an afferent trophic signal that modulates calbindin‐28kD in adult Purkinje cells
TLDR
Normal levels of IGF‐I in the inferior olive are necessary to maintain appropriate levels of insulin‐like growth factor I in the cerebellum and of calbindin‐28kD in the Purkinje cell, extending the previous findings on the existence of an olivo‐cerebellar IGF-I‐containing pathway with trophic influence on the adult Purkin Je cell. Expand
Fenofibrate, a PPAR{alpha} agonist, decreases atrogenes and myostatin expression and improves arthritis-induced skeletal muscle atrophy.
TLDR
The results indicate that, in experimental arthritis, fenofibrate decreases skeletal muscle atrophy through inhibition of the ubiquitin-proteasome system and myostatin. Expand
Long-term Changes in Corneal Morphology Induced by Overnight Orthokeratology
TLDR
Overnight orthokeratology induces structural and optical changes particularly in the central corneal epithelium during myopia treatment, and irreversible changes detected indicate a need for further investigation. Expand
Transynaptic modulation by insulin-like growth factor I of dendritic spines in Purkinje cells
TLDR
Ulastructural analysis of the cerebellar cortex of these animals showed a significant reduction in the size of dendritic spines on Purkinje cells of antisense‐treated rats compared to controls, and this reduction was linked to a diminished numerical density of spines, without affecting the numericaldensity of synapses in the molecular layer of the Cerebellum. Expand
Genotype distribution of cervical human papillomavirus DNA in women with cervical lesions in Bioko, Equatorial Guinea
TLDR
The frequency of HPV types in the African area varies in comparison to other regions, particularly in Europe and USA, and vaccination against the five most common HPV types should be considered in the geographic region of West Africa and specifically in Equatorial Guinea. Expand
Systemic α-melanocyte-stimulating hormone administration decreases arthritis-induced anorexia and muscle wasting.
TLDR
Data show that in arthritic rats peripheral α-MSH treatment has an anti-cachectic action increasing food intake and decreasing muscle wasting. Expand
Fenofibrate administration to arthritic rats increases adiponectin and leptin and prevents oxidative muscle wasting
TLDR
In oxidative muscle, fenofibrate treatment is able to prevent arthritis-induced muscle wasting by decreasing Murf1 and myostatin expression and also by increasing the myogenic regulatory factors, MyoD and myogenin. Expand
Insulin-like growth factor-I modulation of cerebellar cell populations is developmentally stage-dependent and mediated by specific intracellular pathways
TLDR
Insulin-like growth factor-I is a paracrine/autocrine pleiotrophic factor for both glia and neurons in the cerebellum and its effects are mediated by distinct intracellular signals and appear to be specific to the developmental stage of the target cell. Expand
Orthograde transport and release of insulin‐like growth factor I from the inferior olive to the cerebellum
TLDR
Results indicate that the olivo‐cerebellar pathway is able to take up, orthogradely transport, and release IGF‐I, which is proposed to constitute afferent trophic signals involved in plastic mechanisms within specific neural circuitries. Expand
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