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Interaction between opioid agonists or naloxone and 5-HTP on feeding behavior in food-deprived rats
TLDR
The results appear to suggest that central or peripheral opioid receptors differentially affect feeding behavior in the rat and, on the other hand, that the interaction of opiates with the serotonergic system appears to occur preferentially in the periphery. Expand
Impairment by apomorphine of one-trial passive avoidance learning in mice: The opposing roles of the dopamine and noradrenaline systems
TLDR
Pretraining administration of the dopaminergic stimulant apomorphicine impaired retention performance of mice on a one-trial passive avoidance task and, when combined with a subeffective dose of apomorphine, impaired passive avoidance learning, interpreted in terms of the proposed inhibitory actions exerted by central noradrenaline on dopamine systems of the brain. Expand
Analgesic activity of substance P in rats: tolerance and cross-tolerance with enkephalin.
TLDR
The present data suggest that the analgesic effect of SP is mediated by enkephalin release at supraspinal levels which are related to pain control. Expand
Antagonism of diazepam-induced feeding in rats by antisera to opioid peptides.
TLDR
The possible central participation of both beta-endorphin and met-enkephalin in the ingestive behavior induced by diazepam gives further support to the postulated physiological role of endogenous opioids in appetite regulation. Expand
β-Amyloid-Induced Cytotoxicity, Peroxide Generation and Blockade of Glutamate Uptake in Cultured Astrocytes
TLDR
Dithiothreitol, N-acetylcysteine (NAC) and cyclosporine A significantly prevented the toxic effects of both βA25–35 and peroxide, while inhibition of peroxide detoxifying enzymes enhanced toxicity. Expand
Effects of thiophene analogues of chloroamphetamines on central serotonergic mechanisms.
TLDR
Ring-chlorinated thienylisopropylamines, thiophene analogues of chloroamphetamines, have been synthesized and their effects on serotonergic mechanisms in the rat brain have been evaluated and the inhibition of serotonin uptake was more marked than the serotonin depleting property. Expand
Synthesis and pharmacological study of the thiophene analogue of taclamine, QM-7184, a new neuroleptic drug with potent alpha-adrenoceptor blocking activity.
TLDR
This new drug shows a neuroleptic profile in rodents and a high affinity for alpha-noradrenergic receptors, both in the cortex and in the striatum, which is about 20 and 90 times higher than those of haloperidol and butaclamol, respectively. Expand
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