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Modern Catalytic Methods for Organic Synthesis with Diazo Compounds: From Cyclopropanes to Ylides
Synthesis of Alpha-Diazocarbonyl Compounds. Catalysts for Metal Carbene Transformations. Insertion Reactions. Intermolecular Cyclopropanation and Related Addition Reactions. IntramolecularExpand
Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.
The composite experimental results are interpreted to describe alkyl nitrite, and, presumably, nitrous acid association with hemoglobin followed by rate-limiting electron transfer resulting in nitric oxide and alkoxide (or hydroxide) production. Expand
Oxidation of nitrogen oxides by bound dioxygen in hemoproteins.
Details are provided of the stoichiometric transformation through which nitric oxide is converted to nitrate with accompanying oxidation of myoglobin or hemoglobin to the corresponding iron(III) hemoprotein, including an estimate of the rate constant. Expand
The new chemical biology of nitrite reactions with hemoglobin: R-state catalysis, oxidative denitrosylation, and nitrite reductase/anhydrase.
This Account reviews three novel metal- and nitrite-catalyzed reaction pathways in the context of historical studies of nitrite and hemoglobin chemistry and attempts to place them in the biological framework of hypoxic signaling. Expand
Catalytic carbene insertion into C-H bonds.
Recent Advances in Asymmetric Catalytic Metal Carbene Transformations.
Basic Organic Stereochemistry
Preface. Introduction. Structure. Stereoisomers. Symmetry. Configuration. Properties of Stereoisomers and Stereoisomer Discrimination. Separation of Stereoisomers, Resolution, and Racemization.Expand
Oxidation of hemoglobin and myoglobin by alkyl nitrites inhibition by oxygen.
The reactions of human hemoglobin and sperm whale myoglobin with ethyl nitrite under aerobic conditions have been examined in kinetic detail and the effects of organic phosphates on rates for hemoglobin oxidations are interpreted in terms of oxidation inhibition by molecular oxygen. Expand