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Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.
Hypoxia induces rapid and dramatic changes in cellular metabolism, in part through inhibition of target of rapamycin (TOR) kinase complex 1 (TORC1) activity. Genetic studies have shown the tuberousExpand
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p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis.
We demonstrate that deltaNp63alpha is an essential survival factor in head and neck squamous cell carcinoma (HNSCC) through its ability to suppress p73-dependent apoptosis. Inhibition of endogenousExpand
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Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.
PDK1 (3-phosphoinositide-dependent protein kinase 1) activates a group of protein kinases belonging to the AGC [PKA (protein kinase A)/PKG (protein kinase G)/PKC (protein kinase C)]-kinase familyExpand
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Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis
The HIF family of hypoxia-inducible transcription factors are key mediators of the physiologic response to hypoxia, whose dysregulation promotes tumorigenesis. One important HIF-1 effector is theExpand
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The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers.
Breast cancers lacking estrogen and progesterone receptor expression and Her2 amplification exhibit distinct gene expression profiles and clinical features, and they comprise the majority ofExpand
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Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma.
p63 is essential for normal epithelial development and is overexpressed in the vast majority of squamous cell carcinomas (SCC). Recent work had shown that DeltaNp63alpha is essential for survival ofExpand
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Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity
Activation of the inositol-requiring enzyme-1 alpha (IRE1α) protein caused by endoplasmic reticulum stress results in the homodimerization of the N-terminal endoplasmic reticulum luminal domains,Expand
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Abstract 5449: FP-1039/GSK3052230, an FGF ligand trap, enhances VEGF antagonist therapy in preclinical models of RCC and HCC
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA An increasing body of evidence has implicated FGF2 as one of the drivers of resistance to various inhibitors of VEGF-mediatedExpand
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Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230
Fibroblast growth factor (FGF) ligand-dependent signaling has a fundamental role in cancer development and tumor maintenance. GSK3052230 (also known as FP-1039) is a soluble decoy receptor thatExpand
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Tumor-Specific p 73 Up-regulation Mediates p 63 Dependence in Squamous Cell Carcinoma
p63 is essential for normal epithelial development and is overexpressed in the vast majority of squamous cell carcinomas (SCC). Recent work had shown that #Np63A is essential for survival of SCCExpand
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