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Effects of Drugs of Abuse on Putative Rostromedial Tegmental Neurons, Inhibitory Afferents to Midbrain Dopamine Cells
The results suggest that activity of RMTg neurons is profoundly influenced by drugs of abuse and, as important inhibitory afferents to midbrain DA neurons, they might take place in the complex interplay between the neural circuits mediating aversion and reward. Expand
Adolescent exposure to nicotine and/or the cannabinoid agonist CP 55,940 induces gender-dependent long-lasting memory impairments and changes in brain nicotinic and CB1 cannabinoid receptors
Both, nicotine and cannabinoid treatments induced a long-lasting increase in CB1 receptor activity (CP-stimulated GTPγS binding) in male rats and the nicotine treatment also induced a decrease in nicotinic receptor density in the prefrontal cortex of females. Expand
Native CB1 receptor affinity, intrinsic activity and accumbens shell dopamine stimulant properties of third generation SPICE/K2 cannabinoids: BB-22, 5F-PB-22, 5F-AKB-48 and STS-135
3rd generation cannabinoids can be even more potent and super-high CB1 receptor agonists compared to JWH-018 and future research will try to establish if these properties can explain the high toxicity and lethality associated with these compounds. Expand
NMDARs Mediate the Role of Monoamine Oxidase A in Pathological Aggression
The findings suggest that the role of MAO A in pathological aggression may be mediated by changes in NMDAR subunit composition in the PFC, and point to a critical function of this receptor in the molecular bases of antisocial personality. Expand
(-)S amisulpride binds with high affinity to cloned dopamine D(3) and D(2) receptors.
The results show that (-)S amisulpride is the active enantiomer of amisULpride, showing high affinity for dopamine D(3) and dopamineD(2) receptors. Expand
Distribution of GABA(B) receptor mRNAs in the rat brain and peripheral organs.
Both isoforms of the GABA(B) receptor are expressed not only throughout the brain but also in all peripheral organs examined, including heart, spleen, lung, liver, small intestine, large intestine, kidney, stomach, adrenal, testis, ovary and urinary bladder. Expand
Regional distribution of 5α-reductase type 2 in the adult rat brain: An immunohistochemical analysis
Findings show that, in the adult brain, 5αR2 is distributed in critical regions for behavioral regulation, suggesting that the functional role of this isoform is present throughout the entire lifespan of the individual. Expand
Male and female rats differ in brain cannabinoid CB1 receptor density and function and in behavioural traits predisposing to drug addiction: effect of ovarian hormones.
The findings provide biochemical evidence for sex- and hormone- dependent differences in the density and function of CB1 receptors in selected brain regions, and in behaviours associated with greater vulnerability to drug addiction, revealing a more vulnerable behavioural phenotype in female than in male rats. Expand
Quantitative autoradiographic distribution of gamma-hydroxybutyric acid binding sites in human and monkey brain.
The first report on the autoradiographic distribution of specific GHB binding sites in the primate and human brain is reported: such distribution is in both species in good agreement with the distribution found in the rat brain. Expand
Multi-faceted aspects of gamma-hydroxybutyric acid: a neurotransmitter, therapeutic agent and drug of abuse.
  • M. P. Castelli
  • Medicine
  • Mini reviews in medicinal chemistry
  • 30 September 2008
In vivo and in vitro pharmacological properties of GHB and its interaction withGHB and GABA(B) receptors are reviewed and the abuse liability and reinforcing properties ofGHB in humans and laboratory animals are focused on. Expand