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Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.
Several new antidepressants that inhibit the serotonin (SERT) and norepinephrine transporters (NET) have been introduced into clinical practice the past several years. This report focuses on theExpand
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The role of corticotropin-releasing factor in depression and anxiety disorders.
Corticotropin-releasing factor (CRF), a 41 amino acid-containing peptide, appears to mediate not only the endocrine but also the autonomic and behavioral responses to stress. Stress, in particularExpand
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Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder.
OBJECTIVE Corticotropin-releasing factor (CRF) and somatostatin both play important roles in mediating responses to acute and chronic stress. The purpose of this study was to measure CSFExpand
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Physiology and pharmacology of corticotropin-releasing factor.
a showcase for important review articles in your field, featuring longer papers on topics of high current interest. PHARMACOLOGICAL REVIEWS continues to publish the important, longer papers ofExpand
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Neurotensin and dopamine interactions.
Interactions between the classical monoamine neurotransmitter dopamine (DA) and the peptide neurotransmitter neurotensin (NT) in the central nervous system (CNS) have now been investigated for overExpand
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Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine.
BACKGROUND Single isomers of the selective serotonin reuptake inhibitors citalopram (escitalopram, S-citalopram) and fluoxetine (R-fluoxetine) are currently under development for the treatment ofExpand
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Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood
There is increasing evidence for an important role of adverse early experience on the development of major psychiatric disorders in adulthood. Corticotropin-releasing factor (CRF), an endogenousExpand
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The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density
BackgroundA 40-bp variable number of tandem repeats (VNTR) polymorphism exists in the 15th exon of DAT1, the gene encoding the human dopamine transporter (DAT). Though the VNTR resides in a regionExpand
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Depression, Antidepressants, and Neurogenesis: A Critical Reappraisal
The neurogenesis hypothesis of depression posits (1) that neurogenesis in the subgranular zone of the dentate gyrus is regulated negatively by stressful experiences and positively by treatment withExpand
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Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter.
Considerable evidence has accrued in the last two decades to support the hypothesis that alterations in serotonergic neuronal function in the central nervous system occur in patients with majorExpand
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