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Effect of cyclosporine on reperfusion injury in acute myocardial infarction.
BACKGROUND Experimental evidence suggests that cyclosporine, which inhibits the opening of mitochondrial permeability-transition pores, attenuates lethal myocardial injury that occurs at the time ofExpand
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Postconditioning the Human Heart
Background— In animal models, brief periods of ischemia performed just at the time of reperfusion can reduce infarct size, a phenomenon called postconditioning. In this prospective, randomized,Expand
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Regional Ischemic 'Preconditioning' Protects Remote Virgin Myocardium From Subsequent Sustained Coronary Occlusion
BackgroundOne or more brief episodes of coronary artery occlusion protect or “precondition” the myocardium perfused by that artery from a subsequent episode of sustained ischemia. We sought toExpand
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Cyclosporine before PCI in Patients with Acute Myocardial Infarction.
BACKGROUND Experimental and clinical evidence suggests that cyclosporine may attenuate reperfusion injury and reduce myocardial infarct size. We aimed to test whether cyclosporine would improveExpand
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Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology.
Ischaemic postconditioning (brief periods of ischaemia alternating with brief periods of reflow applied at the onset of reperfusion following sustained ischaemia) effectively reduces myocardialExpand
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Postconditioning Inhibits Mitochondrial Permeability Transition
Background—Brief periods of ischemia performed just at the time of reperfusion can reduce infarct size, a phenomenon called “postconditioning.” After reflow, opening of the mitochondrial permeabilityExpand
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Evolving therapies for myocardial ischemia/reperfusion injury.
The damage inflicted on the myocardium during acute myocardial infarction is the result of 2 processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the last 3 decades,Expand
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A fresh look at reperfusion injury.
Time for primary review 25 days. In clinical therapy of evolving acute myocardial infarction, coronary reperfusion has proven to be the only way to limit infarct size, provided it occurs soon enoughExpand
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Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury.
The aim of the present study was to determine whether specific inhibition of mitochondrial permeability transition (MPT) by NIM811 at the time of reperfusion following acute myocardial infarction mayExpand
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Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance
Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) are functional domains between both organelles involved in Ca2+ exchange, through the voltage-dependent anion channelExpand
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