M. Otto

Publications81
h-index18
Citations1,538
Highly Influential Citations56
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Neurofilaments in the diagnosis of motoneuron diseases: a prospective study on 455 patients
Objectives Biomarkers for the diagnosis of motoneuron diseases (MND) are urgently needed to improve the diagnostic pathway, patient stratification and monitoring. The aim of this study was to… Expand
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14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′-rich switch regions for class switch recombination
Class switch DNA recombination (CSR) is the mechanism that diversifies the biological effector functions of antibodies. Activation-induced cytidine deaminase (AID), a key protein in CSR, targets… Expand
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Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options
Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These… Expand
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Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of…
Abstract In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task… Expand
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Neurofilament light chain: a biomarker for genetic frontotemporal dementia
To evaluate cerebrospinal fluid (CSF) and serum neurofilament light chain (NfL) levels in genetic frontotemporal dementia (FTD) as a potential biomarker in the presymptomatic stage and during the… Expand
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TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
BACKGROUND Recently, TAR DNA-binding protein 43 (TDP-43) was identified as the major component of ubiquitin-positive tau-negative neuronal and glial inclusions in the most common form of… Expand
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Subcutaneous immunoglobulin in responders to intravenous therapy with chronic inflammatory demyelinating polyradiculoneuropathy
We hypothesized that subcutaneous administration of immunoglobulins (SCIG) in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is feasible, safe and superior to treatment with saline… Expand
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Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study
PET and CSF biomarkers of amyloid-β are considered interchangeable in defining ‘amyloid positivity’. However, Leuzy et al. report discordance between these measures in a multicentre memory clinic… Expand
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Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS
Abstract Despite major advances in deciphering the neuropathological hallmarks of amyotrophic lateral sclerosis (ALS), validated neurochemical biomarkers for monitoring disease activity, earlier… Expand
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Predicting primary progressive aphasias with support vector machine approaches in structural MRI data
TLDR
We used support vector machine classification on grey matter density maps obtained by voxel-based morphometry analysis to discriminate PPA subtypes (44 patients: 16 nonfluent/agrammatic variant PPA) from 20 healthy controls (matched for sample size, age, and gender). Expand
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