• Publications
  • Influence
Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA
TLDR
A previously uncharacterized set of S. aureus virulence factors are revealed that account at least in part for the enhanced virulence of CA-MRSA. Expand
Staphylococcus epidermidis — the 'accidental' pathogen
  • M. Otto
  • Biology, Medicine
  • Nature Reviews Microbiology
  • 1 August 2009
TLDR
The molecular basis of the commensal and infectious lifestyles of S. epidermidis is discussed, beginning to comprehend the roles in balancing the epithelial microflora and serving as a reservoir of resistance genes. Expand
Inactivation of the dlt Operon inStaphylococcus aureus Confers Sensitivity to Defensins, Protegrins, and Other Antimicrobial Peptides*
TLDR
A role of thed-alanine-esterified teichoic acids which occur in many pathogenic bacteria in the protection against human and animal defense systems is proposed. Expand
Community-associated meticillin-resistant Staphylococcus aureus
TLDR
These features suggest that CA-MRSA strains are more virulent and transmissible than are traditional hospital-associated MRSA strains, and the restricted treatment options for CA- MRSA infections compound the effect of enhanced virulence and transmission. Expand
Staphylococcal biofilms.
  • M. Otto
  • Medicine
  • Current topics in microbiology and immunology
  • 2008
TLDR
Novel animal models of staphylococcal biofilm-associated infection have given important information on which factors define biofilm formation in vivo, and constitute an important basis for the development of anti-staphylitiscal drugs and vaccines. Expand
Staphylococcus aureus Resistance to Human Defensins and Evasion of Neutrophil Killing via the Novel Virulence Factor Mprf Is Based on Modification of Membrane Lipids with l-Lysine
TLDR
A novel staphylococcal gene, mprF, which determines resistance to several host defense peptides such as defensins and protegrins constitutes a novel virulence factor, which may be of general relevance for bacterial pathogens and represents a new target for attacking multidrug resistant bacteria. Expand
A Crucial Role for Exopolysaccharide Modification in Bacterial Biofilm Formation, Immune Evasion, and Virulence*
TLDR
It is demonstrated that the surface-attached protein IcaB is responsible for deacetylation of the poly-N-acetylglucosamine molecule, which was essential for key virulence mechanisms of S. epidermidis and constitutes an excellent target for therapeutic maneuvers aimed at combating biofilm-associated infection. Expand
RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus.
TLDR
It is demonstrated that the Staphylococcus aureus agr quorum-sensing regulon is divided into control of metabolism and PSM cytolysin genes, which occurs independently of the small regulatory RNA RNAIII, and RNAIII-dependent control of additional virulence genes. Expand
Staphylococcal infections: mechanisms of biofilm maturation and detachment as critical determinants of pathogenicity.
  • M. Otto
  • Biology, Medicine
  • Annual review of medicine
  • 17 January 2013
TLDR
Findings substantiate that quorum sensing and surfactants have widespread importance for biofilm maturation processes in bacteria and establish a novel theory of the molecular determinants driving dissemination of biofilm-associated infection. Expand
Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus
  • M. Li, B. Diep, +6 authors M. Otto
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 7 April 2009
TLDR
The results indicate that increased virulence in the USA300/USA500 sublineage is attributable to differential expression of core genome-encoded virulence determinants, such as phenol-soluble modulins and α-toxin, and highlights the importance of differential gene expression in the evolution of USA300 virulence. Expand
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