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Lipid Mediators in Acne
TLDR
Recent data suggest that lipid mediators are able to interfere with sebocytes differentiation and sebogenesis through the activation of pathways related to peroxisome proliferators-activated receptors. Expand
Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris.
TLDR
The present data further support the involvement of lipid peroxides, in particular squalene peroxide, in establishing an inflammatory process in acne. Expand
Membrane lipid alterations as a possible basis for melanocyte degeneration in vitiligo.
TLDR
It is hypothesized that in vitiligo melanocytes lipid instability, with a defect in the synthesis or recycling of CL, induces ETC impairment and ROS production, which leads to cell death or detachment following chemical or physical stress. Expand
Sebaceous gland lipids
TLDR
Understanding the factors and mechanisms that regulate sebum production is needed in order to identify new targets that could be addressed to achieve a selective modulation of lipid biosynthesis as a novel therapeutic strategy to correct lipid disregulations in acne and other disorders of the pilosebaceous unit. Expand
Antioxidants and narrow band‐UVB in the treatment of vitiligo: a double‐blind placebo controlled trial
Background.  Vitiligo is an acquired depigmenting disease with uncertain aetiopathogenesis, possibly associated with oxidative stress. Narrowband ultraviolet B phototherapy (NB‐UVB) is the mostExpand
The eumelanin intermediate 5,6-dihydroxyindole-2-carboxylic acid is a messenger in the cross-talk among epidermal cells.
TLDR
The hitherto unrecognized role of DHICA as an antiproliferative, protective, and antiapoptotic endogenous cell messenger points to a reappraisal of the biological functions of melanocytes and DCT in skin homeostasis and photoprotection beyond the mere provision of melanin pigments. Expand
Acne and smoking
TLDR
The clinical evidences and the experimental data showed a straight correlation between smoking habit and post-pubertal acne in which the non-inflammatory form (NIA) is the most frequent. Expand
Vitiligo: A Possible Model of Degenerative Diseases
TLDR
In this study, in vitro characterization of melanocytes cultures from non-lesional vitiligo skin revealed at the cellular level aberrant function of signal transduction pathways common with neurodegenerative diseases including modification of lipid metabolism, hyperactivation of mitogen-activated protein kinase (MAPK) and cAMP response element-binding protein (CREB), constitutive p53-dependent stress signalTransduction cascades, and enhanced sensibility to pro-apoptotic stimuli. Expand
Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARγ activation
TLDR
Azelaic acid modulates the inflammatory response in normal human keratinocytes through PParγ activation through PPARγ activation. Expand
Membrane lipid defects are responsible for the generation of reactive oxygen species in peripheral blood mononuclear cells from vitiligo patients
TLDR
The modification of membrane lipid components in vitiligo cells may be the biochemical basis for the mitochondrial impairment and the subsequent production of intracellular ROS following the exposure to a mild stress. Expand
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