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Mitochondria, oxidative stress and cell death
In addition to the well-established role of the mitochondria in energy metabolism, regulation of cell death has recently emerged as a second major function of these organelles. This, in turn, seemsExpand
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Cytochrome c release from mitochondria proceeds by a two-step process
Cytochrome c is often released from mitochondria during the early stages of apoptosis, although the precise mechanisms regulating this event remain unclear. In this study, with isolated liverExpand
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Ribosome binding to the Oxa1 complex facilitates co‐translational protein insertion in mitochondria
The Oxa1 translocase of the mitochondrial inner membrane facilitates the insertion of both mitochondrially and nuclear‐encoded proteins from the matrix into the inner membrane. Most mitochondriallyExpand
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Cbp3–Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly
A complex specifically required for the biogenesis of the respiratory chain component cytochrome b binds to the tunnel exit of yeast mitochondrial ribosomes to coordinate protein synthesis andExpand
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Mba1, a membrane‐associated ribosome receptor in mitochondria
The genome of mitochondria encodes a small number of very hydrophobic polypeptides that are inserted into the inner membrane in a cotranslational reaction. The molecular process by whichExpand
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Co-translational membrane insertion of mitochondrially encoded proteins.
The components of the mitochondrial proteome represent a mosaic of dual genetic origin: while most mitochondrial proteins are encoded by nuclear genes and imported into the organelle followingExpand
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Organization and Regulation of Mitochondrial Protein Synthesis.
Mitochondria are essential organelles of endosymbiotic origin that are responsible for oxidative phosphorylation within eukaryotic cells. Independent evolution between species has generatedExpand
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The Cbp3–Cbp6 complex coordinates cytochrome b synthesis with bc1 complex assembly in yeast mitochondria
The Cbp3–Cbp6 complex, which has been shown previously to promote cytochrome b synthesis and assembly, plays a key role in adjusting cytochrome b expression to the efficiency of assembly of theExpand
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Evolution of Mitochondrial Oxa Proteins from Bacterial YidC
Members of the Oxa1/YidC family are involved in the biogenesis of membrane proteins. In bacteria, YidC catalyzes the insertion and assembly of proteins of the inner membrane. Mitochondria of animals,Expand
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The Mitochondrial TOM Complex Is Required for tBid/Bax-induced Cytochrome c Release*
Cytochrome c release from mitochondria is a key event in apoptosis signaling that is regulated by Bcl-2 family proteins. Cleavage of the BH3-only protein Bid by multiple proteases leads to theExpand
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