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Mitochondria, oxidative stress and cell death
There is accumulating evidence supporting a direct link between mitochondria, oxidative stress and cell death. Expand
Cytochrome c release from mitochondria proceeds by a two-step process
The results indicate that the release of cytochrome c involves a distinct two-step process that is undermined when either step is compromised, and this mechanism also extends to conditions of mitochondrial permeability transition insofar as cy tochrome c release is significantly depressed when the electrostatic interaction between cyto Chrome c and cardiolipin remains intact. Expand
Ribosome binding to the Oxa1 complex facilitates co‐translational protein insertion in mitochondria
It is shown that the matrix‐exposed C‐terminus of Oxa1 forms an α‐helical domain that has the ability to bind to mitochondrial ribosomes, suggesting that co‐translational membrane insertion of mitochondrial translation products is facilitated by a physical interaction of translation complexes with the membrane‐bound translocase. Expand
Cbp3–Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly
A complex specifically required for the biogenesis of the respiratory chain component cytochrome b binds to the tunnel exit of yeast mitochondrial ribosomes to coordinate protein synthesis andExpand
Mba1, a membrane‐associated ribosome receptor in mitochondria
It is proposed that Mba1 functions as a ribosome receptor that cooperates with Oxa1 in the positioning of the ribosomes exit site to the insertion machinery of the inner membrane. Expand
The Cbp3–Cbp6 complex coordinates cytochrome b synthesis with bc1 complex assembly in yeast mitochondria
The Cbp3–Cbp6 complex, which has been shown previously to promote cytochrome b synthesis and assembly, plays a key role in adjusting cytochrome b expression to the efficiency of assembly of theExpand
Co-translational membrane insertion of mitochondrially encoded proteins.
The machinery that mediates membrane insertion in mitochondria is deduced from that of their bacterial ancestors and hence shows profound similarities to the insertion machinery of prokaryotes, which drove a severe reduction in the complexity of this system. Expand
Organization and Regulation of Mitochondrial Protein Synthesis.
This review places the new structural information in the context of the molecular mechanisms of mitochondrial translation and focus on the novel ways protein synthesis is organized and regulated in mitochondria. Expand
Evolution of Mitochondrial Oxa Proteins from Bacterial YidC
YidC is able to functionally replace both Oxa1 and Cox18/Oxa2, suggesting that during evolution of mitochondria from their bacterial ancestors the two descendents of YidC functionally segregated to perform two distinct activities, one co-translational and one post- translational. Expand
An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death
It is shown that a prolonged (∼10 min) increase in intracellular Ca2+ level is a prerequisite step for AIF processing and release during cell death, andhibition of calpain, or chelation of Ca2+, but not the suppression of caspase activity, preventedprocessing and release of AIF. Expand