M. Otsuka

Publications51
h-index17
Citations619
Highly Influential Citations9
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Involvement of phosphatidylinositol‐3‐kinase and ERK pathways in the production of TGF‐β1 by macrophages treated with liposomes composed of phosphatidylserine
We explored the involvement of phosphatidylinositol 3‐kinase (PI3K) and ERK pathways in the production of TGF‐β1 by macrophages treated with liposomes composed of phosphatidylserine (PS‐liposomes).… Expand
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Involvement of ERK, a MAP kinase, in the production of TGF-beta by macrophages treated with liposomes composed of phosphatidylserine.
We have already reported that TGF-beta could be involved in the inhibitory effects of negatively charged liposomes composed of phosphatidylserine (PS-liposome) on the production of nitric oxide (NO)… Expand
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Phosphatidylserine-specific receptor contributes to TGF-beta production in macrophages through a MAP kinase, ERK.
We explored the involvement of the phosphatidylserine (PS)-receptor in the production of TGF-beta by macrophages treated with PS-liposomes. The binding of anti-PS-receptor antibody to macrophages was… Expand
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Influence of meal distribution of wheat bran on fecal bulk, gastrointestinal transit time and colonic thymidine kinase activity in the rat.
Male Fischer 344 rats were fed either fiber-free (FF), continuous 10% wheat bran (CWB) or intermittent 50% wheat bran (IWB) diets for 6 wk to investigate possible alterations in physiological effects… Expand
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The changes in glycosylation after partial hepatectomy enhance collagen binding of vitronectin in plasma.
Vitronectin is a multifunctional glycoprotein present in the extracellular matrix and plasma. Changes in rat vitronectin were studied during liver regeneration after partial hepatectomy. Carbohydrate… Expand
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Ascorbate indirectly stimulates fatty acid utilization in primary cultured guinea pig hepatocytes by enhancing carnitine synthesis.
L-Ascorbic acid is required for the synthesis of L-carnitine, which is essential for the oxidation of long-chain fatty acids. The purpose of this study was to investigate the role of ascorbate on the… Expand
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An improved high-performance liquid chromatographic assay for the determination of free and esterified carnitine in animal tissues.
A high-performance liquid chromatographic procedure for the determination of carnitine that is converted to coenzyme A(CoA) stoichiometrically by carnitine acetyltransferase is described. The… Expand
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An improved high-performance liquid chromatographic assay for the determination of pyridinoline in connective tissues.
A high-performance liquid chromatographic (HPLC) method for determination of pyridinoline and its application to connective tissues are described. The chromatographic separation was accomplished by… Expand
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Separative determination of ascorbic acid and erythorbic acid by high-performance liquid chromatography.
High-performance liquid chromatography (HPLC) was applied to the determination of ascorbic acid (AsA) and erythorbic acid (ErA). The apparatus was a Shimadzu model LC-2P Liquid Chromatograph equipped… Expand
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Separative determination of ascorbic acid and erythorbic acid in animal tissues by high-performance liquid chromatography.
A method for the separation and determination of ascorbic acid (AsA) and erythorbic acid (ErA) in animal tissues is described. It employs high-performance liquid chromatography on a LiChrosorb-NH2… Expand
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