M. Otsuka

Publications208
h-index42
Citations7,198
Highly Influential Citations75
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Physiological and chemical architecture of a lobster ganglion with particular reference to gamma-aminobutyrate and glutamate.
THERE IS LITTLE DOUBT that gamma-aminobutyric acid (GABA) is the inhibitory transmitter compound at the lobster neuromuscular junction (see 20). Special interest, therefore, is attached to the… Expand
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Substance P: Depletion in the dorsal horn of rat spinal cord after section of the peripheral processes of primary sensory neurons
The substance P content, glutamic acid decarboxylase and choline acetyltransferase activities and the level of [3H]diprenorphine binding were measured in various regions of the lumbar spinal cord of… Expand
  • 453
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Tail-pinch method in vitro and the effects of some antinociceptive compounds
Abstract An in vitro preparation for testing antinociceptive drugs is described. The preparation consists of isolated spinal cord, spinal nerve roots and functionally connected tail of the newborn… Expand
  • 76
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Substance P as an excitatory transmitter of primary afferent neurons in guinea-pig sympathetic ganglia
Electrophysiological and neurochemical experiments were carried out to examine a possible transmitter role substance P in the prevertebral ganglia of the guinea-pig. When potentials were recorded… Expand
  • 178
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Pharmacological properties of a C‐fibre response evoked by saphenous nerve stimulation in an isolated spinal cord‐nerve preparation of the newborn rat
1 An isolated spinal cord‐peripheral nerve preparation of the newborn rat was developed. In this preparation it is possible to record spinal reflexes from a lumbar ventral root in response to… Expand
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Metabolism of afloqualone, a new centrally acting muscle relaxant, in monkeys and dogs.
The disposition and metabolism of afloqualone [6-amino-2-fluoromethyl-3-(o-tolyl)-4(3H)-quinazolinone, AFQ] were studied in monkeys and dogs after oral administration of 14C-AFQ. In both species the… Expand
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Regional distribution of substance P in the spinal cord and nerve roots of the cat and the effect of dorsal root section
Chemical properties of substance P in the spinal cord and dorsal roots of the cat were examined by gel chromatography and paper electrophoresis. The results suggest that the substance is identical… Expand
  • 429
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MEASUREMENT OF γ‐AMINOBUTYRIC ACID IN ISOLATED NERVE CELLS OF CAT CENTRAL NERVOUS SYSTEM
Abstract— A sensitive method for measuring γ‐aminobutyric acid (GABA) has been developed. This method consists of a combination of the enzymic GABA assay of Jakoby and Scott (1959) with the enzymic… Expand
  • 171
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The effects of substance P and baclofen on motoneurones of isolated spinal cord of the newborn rat.
The effects of substance P (SP) and baclofen were studied in the isolated spinal cord of newborn rats. Potential changes generated in motoneurones were recorded extracellularly from the ventral root… Expand
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The effect of guanidine on neuromuscular transmission.
  • M. Otsuka, M. Endo
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 March 1960
The effect of guanidine on neuromuscular transmission was studied in the sciatic-sartorius preparation of the frog, using intracellular electrodes. The sensitivity of the ned-plate to ACh was… Expand
  • 118
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