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Aerosil as a novel co-crystal co-former for improving the dissolution rate of hydrochlorothiazide.
Co-crystallization of drugs with benign co-formers is promising for enhancing dissolution rate of poorly soluble drugs. The selection of safe and pharmacologically inert co-formers is a critical stepExpand
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Penetration enhancers in proniosomes as a new strategy for enhanced transdermal drug delivery.
The aim of this work is to investigate penetration enhancers in proniosomes as a transdermal delivery system for nisoldipine. This was performed with the goal of optimising the composition ofExpand
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Self dispersing mixed micelles forming systems for enhanced dissolution and intestinal permeability of hydrochlorothiazide.
Mixed micelles provide promising strategy for enhancing dissolution and permeability of drugs. However, their fluid nature limited the stability of the loaded drug and hindered the development ofExpand
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Colloidal carriers for extended absorption window of furosemide
The aim was to investigate the potential of self‐microemulsifying drug delivery systems (SMEDDS) and niosomes as carriers for widening the gastrointestinal absorption window of furosemide (modelExpand
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Risk Factors of Viral Hepatitis B among Egyptian Blood Donors
Background: Surveillance of infectious disease markers in the blood donor population is important in recognizing trends in prevalence and incidence of transfusion related infections in asymptomaticExpand
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Polymeric nano-encapsulation of 5-fluorouracil enhances anti-cancer activity and ameliorates side effects in solid Ehrlich Carcinoma-bearing mice.
Biodegradable PLGA nanoparticles, loaded with 5-fluorouracil (5FU), were prepared using a double emulsion method and characterised in terms of mean diameter, zeta potential, entrapment efficiency andExpand
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Skin delivery of nisoldipine from niosome proconcentrate
Article history: Received on: 07/11/2013 Revised on: 21/12/2013 Accepted on: 16/01/2014 Available online: 27/02/2014 Nisoldipine is used for treatment of hypertension and angina pectoris. However, itExpand
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Sucralose as co-crystal co-former for hydrochlorothiazide: development of oral disintegrating tablets
Abstract Development of oral disintegrating tablets requires enhancement of drug dissolution and selection of sweetener. Co-crystallization of drugs with inert co-former is an emerging technique forExpand
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Xylitol as a potential co-crystal co-former for enhancing dissolution rate of felodipine: preparation and evaluation of sublingual tablets
Abstract Dissolution enhancement is a promising strategy for improving drug bioavailability. Co-crystallization of drugs with inert material can help in this direction. The benefit will become evenExpand
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Enhanced cutaneous wound healing in rats following topical delivery of insulin-loaded nanoparticles embedded in poly(vinyl alcohol)-borate hydrogels
Insulin plays an important role in the wound healing process, but its method of delivery to the wound bed and subsequent effect on rate of healing is less well investigated. In this study, weExpand
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