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Soluble metalloendopeptidase from rat brain: action on enkephalin-containing peptides and other bioactive peptides.
A soluble metalloendopeptidase identified in rat brain, preferentially cleaves bonds in peptides having hydrophobic amino acid residues in the P1, P2, and P3' positions. (The nomenclature of T.Expand
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Catalytic activities of the 20 S proteasome, a multicatalytic proteinase complex.
  • M. Orlowski, S. Wilk
  • Biology, Medicine
  • Archives of biochemistry and biophysics
  • 1 November 2000
The proteasome, a multisubunit, multicatalytic proteinase complex, is attracting growing attention as the main intracellular, extralysosomal, proteolytic system involved in ubiquitin-(Ub) dependentExpand
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ISOLATION OF GAMMA-GLUTAMYL TRANSPEPTIDASE FROM HOG KIDNEY.
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-Glutamyl cyclotransferase. Distribution, isozymic forms, and specificity.
Abstract γ-Glutamyl cyclotransferase activity was found in homogenates of 11 rat tissues (kidney, liver, testes, spleen, brain, lung, heart, thymus, thyroid, skeletal muscle, and adrenal); two formsExpand
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A soluble metalloendopeptidase from rat brain. Purification of the enzyme and determination of specificity with synthetic and natural peptides.
A metalloendopeptidase, optimally active at a neutral pH, was purified from the soluble fraction of brain homogenates. The enzyme (molecular weight about 67000) is strongly inhibited by metalExpand
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The γ-Glutamyl Cycle: A Possible Transport System for Amino Acids
Abstract Evidence is presented that rat kidney contains enzymes that catalyze the synthesis and utilization of glutathione; these reactions, which involve the uptake and release of amino acids fromExpand
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A soluble metalloendopeptidase from rat brain
A metalloendopeptidase, optimally active at a neutral pH, was purified from the soluble fraction of brain homogenates. The enzyme (molecular weight about 67000) is strongly inhibited by metalExpand
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CD4 Glycoprotein Degradation Induced by Human Immunodeficiency Virus Type 1 Vpu Protein Requires the Function of Proteasomes and the Ubiquitin-Conjugating Pathway
ABSTRACT The human immunodeficiency virus type 1 (HIV-1) vpugene encodes a type I anchored integral membrane phosphoprotein with two independent functions. First, it regulates virus release from aExpand
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Evidence that Pituitary Cation‐Sensitive Neutral Endopeptidase Is a Multicatalytic Protease Complex
Abstract: Pituitary cation‐sensitive neutral endopeptidase splits peptide bonds on the carboxyl side of hydrophobic amino acids (chymotrypsin‐like activity), basic amino acids (trypsin‐likeExpand
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