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Multicenter evaluation of a new chromogenic factor X assay in plasma of patients on oral anticoagulants.
Abstract A new factor X (FX) assay based on the chromogenic substrate S-2337 was compared with the coagulation screening method Thrombotest (TT) in 1431 plasma samples from 188 patients followed upExpand
Activated partial thromboplastin time. A multicenter evaluation of 11 reagents in the screening of mild haemophilia A.
An internationally standardized preparation and 10 commercial kits widely used to perform the activated partial thromboplastin time (APTT) were compared in 4 laboratories for the purpose of assessingExpand
Factor VII Deficiency: Immunological Characterization of Genetic Variants and Detection of Carriers
There was no correlation between the presence of factor VII:Ag and either the clinical picture or the specific function as studied with the Km calculations. Expand
Structural or functional heterogeneity of normal human serum albumin, allo albumin, bisalbumin.
A comparative isoelectric focusing study of electrophoretically normal and abnormal albumins agrees with the hypothesis that the heterogeneity depends on the structure and the carrier function of albumin. Expand
Multicentre comparison of nine coagulometers and manual tilt-tube methods for prothrombin time performance.
Good or excellent discrimination, as judged by higher Student t values, were achieved slightly more frequently by coagulometers than by manual methods, particularly when paris of plasmas with smaller PT differences were tested. Expand
Factor VII in subjects at risk for thromboembolism: activation or increased synthesis?
The preliminary results obtained by investigating factor VII antigen and activity in 38 subjects with arterial disease of the extremities confirm that elevated levels of factor VII are present in patients with tendency to thrombosis. Expand
Factor VII activity and antigen in haemophilia B variants.
Age, a mild Vitamin K deficiency, the presence of an inhibitor of Factor VII activation and other unknown causes, may be responsible for the prolongation of Ox-brain prothrombin time due to factor VII:C mild deficiency. Expand
Intragenic Factor IX restriction site polymorphism in hemophilia B variants.
CDNA restriction patterns suggest absence of gross rearrangements and/or deletions in all hemophilic patients, indicating that a wide spectrum of mutations underlies this blood-clotting disorder and particularly each of its variants. Expand