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The Columbia-Suicide Severity Rating Scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults.
Findings suggest that the Columbia-Suicide Severity Rating Scale is suitable for assessment of suicidal ideation and behavior in clinical and research settings.
Columbia Classification Algorithm of Suicide Assessment (C-CASA): classification of suicidal events in the FDA's pediatric suicidal risk analysis of antidepressants.
OBJECTIVE To evaluate the link between antidepressants and suicidal behavior and ideation (suicidality) in youth, adverse events from pediatric clinical trials were classified in order to identify
Prospective study of clinical predictors of suicidal acts after a major depressive episode in patients with major depressive disorder or bipolar disorder.
Clinicians may find it useful to assess patients' current level of pessimism, aggressive/impulsive traits, and comorbidity with substance use disorders, including nicotine-related disorders, to help identify patients at risk for suicidal behavior after major depression.
Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression.
Lower expressing transporter alleles, directly and by increasing the impact of stressful life events on severity, explain 31% of the variance in major depression severity.
An Association between a Functional Polymorphism in the Monoamine Oxidase A Gene Promoter, Impulsive Traits and Early Abuse Experiences
The results suggest that the lower expression of the MAOA-uVNTR polymorphism is related to a history of early Abuse and may sensitize males, but not females, to the effects of early abuse experiences on impulsive traits in adulthood.
The relationship of childhood abuse to impulsivity and suicidal behavior in adults with major depression.
Investigating whether a higher frequency of reported childhood trauma would be found in depressed adults with higher levels of trait impulsivity, aggression, and suicidal behavior found that subjects who reported an abuse history were more likely to have made a suicide attempt and had significantly higher impulsivity and aggression scores.
Altered Serotonin 1A Binding in Major Depression: A [carbonyl-C-11]WAY100635 Positron Emission Tomography Study
AN have higher 5-HT(1A) than controls and AE suggesting a model of depression characterized by an over expression of autoinhibitory somatodendritic 5- HT( 1A) receptors, perhaps due to the higher expressing G allele, that may result in reduced terminal field 5-ht release.
Suicidal behavior in bipolar mood disorder: clinical characteristics of attempters and nonattempters.
Bipolar subjects with a history of a suicide attempt experience more episodes of depression, and react to them by having severe suicidal ideation, suggested by a higher level of lifetime aggression and a pattern of repeated suicide attempts.
Volumetric Analysis of the Prefrontal Cortex, Amygdala, and Hippocampus in Major Depression
MRI studies in depressed subjects report smaller volumes of amygdala, hippocampus, inferior anterior cingulate, and the orbital prefrontal cortex, components of the limbic-cortico-thalamic circuit, but no significant volumetric differences were noted in the hippocampus or OPFC.
Religious affiliation and suicide attempt.
Religious affiliation is associated with less suicidal behavior in depressed inpatients and greater moral objections to suicide and lower aggression level in religiously affiliated subjects may function as protective factors against suicide attempts.