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Regulatory T Cells and Immune Tolerance
Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are… Expand
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.
FoxP3 is a key transcription factor for the development and function of natural CD4(+) regulatory T cells (Treg cells). Here we show that human FoxP3(+)CD4(+) T cells were composed of three… Expand
Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease
Summary: Naturally arising CD25+CD4+ regulatory T (Treg) cells, most of which are produced by the normal thymus as a functionally mature T‐cell subpopulation, play key roles in the maintenance of… Expand
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
Naturally arising CD25+CD4+ regulatory T cells (TR cells) are engaged in the maintenance of immunological self-tolerance and immune homeostasis by suppressing aberrant or excessive immune responses,… Expand
HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo
Human T-cell leukemia virus type 1 (HTLV-1) is the causal agent of a neoplastic disease of CD4+ T cells, adult T-cell leukemia (ATL), and inflammatory diseases including HTLV-1 associated… Expand
Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells.
Naturally arising regulatory T (Treg) cells express the transcription factor FoxP3, which critically controls the development and function of Treg cells. FoxP3 interacts with another transcription… Expand
Tissue-Derived Hedgehog Proteins Modulate Th Differentiation and Disease
- A. Furmanski, J. Saldaña, +4 authors T. Crompton
- Biology, Medicine
- The Journal of Immunology
- 15 March 2013
Genome-wide association studies of complex immune-mediated diseases have indicated that many genetic factors, each with individual low risk, contribute to overall disease. It is therefore timely and… Expand
Control of Autoimmune Myocarditis and Multiorgan Inflammation by Glucocorticoid-Induced TNF Receptor Family-Related Proteinhigh, Foxp3-Expressing CD25+ and CD25− Regulatory T Cells1
Anomalies of naturally occurring CD4+ regulatory T cells (Treg) cause severe autoimmune/inflammatory diseases in humans and rodents. The transcription factor Foxp3 is currently the most specific… Expand
Follicular helper T cell signature in type 1 diabetes.
- R. Kenefeck, C. Wang, +11 authors L. Walker
- Biology, Medicine
- The Journal of clinical investigation
- 2 January 2015
The strong genetic association between particular HLA alleles and type 1 diabetes (T1D) indicates a key role for CD4+ T cells in disease; however, the differentiation state of the responsible T cells… Expand
Development of a novel 99mTc-chelate-conjugated bisphosphonate with high affinity for bone as a bone scintigraphic agent.
- K. Ogawa, T. Mukai, Y. Inoue, M. Ono, H. Saji
- Materials Science, Medicine
- Journal of nuclear medicine : official…
- 1 December 2006
UNLABELLED In bone scintigraphy using (99m)Tc with methylenediphosphonate ((99m)Tc-MDP) and hydroxymethylenediphosphonate ((99m)Tc-HMDP), it takes 2-6 h after an injection before imaging can start.… Expand