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Functional analysis of PIK3CA gene mutations in human colorectal cancer.
Mutations in the PIK3CA gene, which encodes the p110alpha catalytic subunit of phosphatidylinositol 3-kinase (PI3K), have been reported in human cancers, including colorectal cancer. Most of the… Expand
Inflammation and cancer: Role of nuclear factor‐kappaB activation
It has been thought that there is a strong relationship between inflammation and carcinogenesis so that the development of cancer occurs with chronic inflammation in many organs. An in‐depth… Expand
Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma.
- H. Ijichi, A. Chytil, +13 authors H. Moses
- Medicine, Biology
- The Journal of clinical investigation
- 3 October 2011
Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal neoplasms, is characterized by an expanded stroma with marked fibrosis (desmoplasia). We previously generated pancreas… Expand
A mouse model of vascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia.
- M. Sata, Y. Maejima, +11 authors R. Nagai
- Journal of molecular and cellular cardiology
- 1 November 2000
Genetically modified mice serve as a powerful tool to determine the role of specific molecules in a wide variety of biological phenomena including vascular remodeling. Several models of arterial… Expand
H. pylori activates NF-κB through a signaling pathway involving IκB kinases, NF-κB—inducing kinase, TRAF2, and TRAF6 in gastric cancer cells☆
Abstract Background & Aims: H. pylori infection on gastric epithelial cells has been shown to induce NF-κB activation, but the mechanism of intracellular signal conduction that leads to NF-κB… Expand
Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma
- H. Takagi, S. Sasaki, +8 authors Y. Shinomura
- Biology, Medicine
- Journal of Gastroenterology
- 1 July 2008
BackgroundActivation of the Wnt signaling pathway is frequently observed in hepatocellular carcinoma (HCC), though mutation of three of its components, CTNNB1, AXIN1, and AXIN2, is observed… Expand
Comparison of unitary displacements and forces between 2 cardiac myosin isoforms by the optical trap technique: molecular basis for cardiac adaptation.
To provide information on the mechanism of cardiac adaptation at the molecular level, we compared the unitary displacements and forces between the 2 rat cardiac myosin isoforms, V1 and V3. A… Expand
Voltage‐gated sodium channel expressed in cultured human smooth muscle cells: involvement of SCN9A
Voltage‐gated Na+ channel (INa) is expressed under culture conditions in human smooth muscle cells (hSMCs) such as coronary myocytes. The aim of this study is to clarify the physiological,… Expand
Crucial Role of Type 1, but Not Type 3, Inositol 1,4,5-Trisphosphate (IP3) Receptors in IP3-Induced Ca2+ Release, Capacitative Ca2+ Entry, and Proliferation of A7r5 Vascular Smooth Muscle Cells
Abstract — Stimulation of G protein– or tyrosine kinase–coupled receptors regulates cell proliferation through intracellular Ca2+ ([Ca2+]i) signaling. In A7r5 cells, we confirmed that inositol… Expand
p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells.
The activation of Hedgehog (Hh) signaling has been implicated in the growth of various tumor types, including gastric carcinoma. However, the precise mechanisms of Hh activation and suppression of… Expand