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Acute kidney injury associated with cardiac surgery.
No single strategy has demonstrated conclusively its ability to prevent renal injury after bypass surgery, but several compounds such as atrial natriuretic peptide and N-acetylcysteine have shown promise, but large-scale trials are needed. Expand
IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury.
- L. Li, Liping Huang, +6 authors M. Okusa
- Biology, Medicine
- The Journal of clinical investigation
- 4 January 2010
The results demonstrate that the innate immune component of kidney IRI requires dual activation of the IL-12/IFN-gamma and IL-23/IL-17 signaling pathways and that neutrophil production of IL-17A is upstream ofIL-12 /IFN/gamma signaling, which might contribute to reperfusion injury in other organs. Expand
NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury.
The results support the essential role of NKT cells and neutrophils in the innate immune response of renal IRI by mediating neutrophil infiltration and production of IFN-gamma. Expand
Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury.
- G. R. Kinsey, Rahul Sharma, +5 authors M. Okusa
- Journal of the American Society of Nephrology…
- 1 August 2009
Results demonstrate that Tregs modulate injury after kidney IRI through IL-10-mediated suppression of the innate immune system. Expand
The chemokine receptors CCR2 and CX3CR1 mediate monocyte/macrophage trafficking in kidney ischemia-reperfusion injury.
This study shows that inflamed monocyte migration, through CCR2- and CX3CR1-dependent mechanisms, plays a critical role in kidney injury following ischemia reperfusion. Expand
A basic science view of acute kidney injury biomarkers.
- J. Charlton, D. Portilla, M. Okusa
- Nephrology, dialysis, transplantation : official…
- 1 July 2014
This review will underscore the biological basis of specific biomarkers that will contribute to the advancement in the treatment and outcomes of AKI. Expand
Inflammation in Acute Kidney Injury
A review of recent advances in understanding the immune mechanisms of acute kidney injury concludes that the complex interplay between innate and adaptive immunity in renal IRI is still not completely understood, but major advances have been made. Expand
Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages.
- Y. Day, Liping Huang, H. Ye, J. Linden, M. Okusa
- American journal of physiology. Renal physiology
- 1 April 2005
It is concluded that the full extent of ischemia-reperfusion injury requires macrophages and that A(2A) agonist-mediated tissue protection is independent of activation of macrophage A( 2A)Rs. Expand
Activation of Adenosine 2A Receptors Attenuates Allograft Rejection and Alloantigen Recognition1
It is concluded that A2AR agonists may represent a new class of compounds for induction therapy in organ transplantation and attenuate allogenic immune activation by action on both T lymphocytes and APCs in vitro and delayed acute rejection in vivo. Expand
Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.
- B. M. Kenwood, Janelle L Weaver, +23 authors K. Hoehn
- Biology, Medicine
- Molecular metabolism
- 1 April 2014
BAM15 is bioactive in vivo and dose-dependently protects mice from acute renal ischemic-reperfusion injury and its reduced toxicity will hopefully reignite interest in pharmacological uncoupling for the treatment of the myriad of diseases that are associated with altered mitochondrial function. Expand