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Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro.
It is suggested that IL-6 functions as a paracrine growth factor for LNCaP and as an autocrine growth factors for DU145 and PC3, but it has no stimulatory effect on epithelial cells derived from BPH. Expand
Mechanism of Anticancer Host Response Induced by OK-432, a Streptococcal Preparation, Mediated by Phagocytosis and Toll-Like Receptor 4 Signaling
- M. Okamoto, T. Oshikawa, +9 authors Mitsunobu Sato
- Biology, Medicine
- Journal of immunotherapy
- 1 January 2006
In in vivo experiments, the anticancer effect of OK-432 was significantly inhibited by suppression of phagocytosis activity by cytochalasin B, and in vitro experiments elucidated the mechanism mediated by phagocytes and TLR4 signaling in the immune effect ofOK-432. Expand
Expression of Toll-Like Receptor 4 on Dendritic Cells Is Significant for Anticancer Effect of Dendritic Cell-Based Immunotherapy in Combination with an Active Component of OK-432, a Streptococcal…
It is suggested that OK-PSA may be a potent adjuvant for local DC therapy, and that DC therapy followed by OK- PSA is able to elicit anticancer activity even in aTLR4-deficient host when TLR4 is expressed only in DCs injected intratumorally. Expand
Prognostic Significance of Interleukin-8 and CD163-Positive Cell-Infiltration in Tumor Tissues in Patients with Oral Squamous Cell Carcinoma
Findings indicate that IL-8 may be involved in poor clinical outcomes via generation of CD163-positive M2 macrophages from peripheral blood monocytes and that these factors in addition to N status may have prognostic value in patients with resectable OSCSS. Expand
Mechanism for bone invasion of oral cancer cells mediated by interleukin‐6 in vitro and in vivo
Although interleukin (IL)‐6 accelerates osteoclastic bone resorption, it remains unclear whether IL‐6 may be involved in bone invasion of oral cancer. Expand
Involvement of Toll-like receptor 4 signaling in interferon-gamma production and antitumor effect by streptococcal agent OK-432.
- M. Okamoto, T. Oshikawa, +13 authors Mitsunobu Sato
- Biology, Medicine
- Journal of the National Cancer Institute
- 19 February 2003
TLR4 and MD-2 may mediate OK-432-induced anticancer immunity and be associated with the in vivo IFN-gamma induction in 19 patients administeredOK-432. Expand
Toll-like receptor signaling in anti-cancer immunity.
- M. Okamoto, Mitsunobu Sato
- Biology, Medicine
- The journal of medical investigation : JMI
- 1 February 2003
It is demonstrated that TLR4 signaling is intimately involved in anti-cancer immunity induced by these immunopotentiators, and the clinical examination in oral cancer patients also suggests the requirement of bothTLR4 and MD-2 in the OK-432-induced anti- cancer host response. Expand
Biological effect of OK-432 (picibanil) and possible application to dendritic cell therapy.
- Yoshiki Ryoma, Y. Moriya, M. Okamoto, I. Kanaya, M. Saito, Mitsunobu Sato
- Anticancer research
- 1 September 2004
Results suggest that OK-432 is a useful adjuvant in DC-based anticancer immunotherapy, and dendritic cells are considered to play a pivotal role in immunological response. Expand
The feasibility and clinical effects of dendritic cell-based immunotherapy targeting synthesized peptides for recurrent ovarian cancer
The results demonstrated the feasibility and potential clinical effectiveness of DC-based immunotherapy for ROC patients and suggested a good nutritional status might be an important factor for further clinical effects. Expand
Impact of dendritic cell vaccines pulsed with Wilms' tumour-1 peptide antigen on the survival of patients with advanced non-small cell lung cancers.
- Hidenori Takahashi, M. Okamoto, +5 authors Y. Yonemitsu
- European journal of cancer
- 1 March 2013
This study is the first to suggest that DC vaccines pulsed with WT1 may hold a significant impact to prolong the overall survival of patients with advanced NSCLCs. Expand