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Experimental studies on the role of fructose in the development of diabetic complications.
Fructose is considered to be a more critical reducing sugar associated with the progression of diabetic complications than it has been thought until now. Expand
Effect of neuropeptide Y on the hypothalamic-pituitary-adrenal axis in the dog.
The present findings that NPY evokes ACTH secretion and potentiates the effectiveness of CRF as a secretagogue, together with high concentrations of NPY in the hypothalamus and pituitary portal blood, suggest thatNPY is involved in the multihormonal control of ACTH release. Expand
Increased cholesterol concentration in intermediate density lipoprotein fraction of normolipidemic non-insulin-dependent diabetics.
Findings indicate an increased risk factor in normolipidemic diabetics of atherosclerosis, as a significant increase in cholesterol concentration was found in IDL1 of groups S and D. Expand
Increase in 3-deoxyglucosone levels in diabetic rat plasma. Specific in vivo determination of intermediate in advanced Maillard reaction.
Determination of 3-DG represents a good tool to predict development and progression of diabetic complications and to assess the efficiency of inhibitors to Maillard reaction. Expand
Glycation of cataractous lens in non-diabetic senile subjects and in diabetic patients.
The results suggest that advanced-stage products in the Maillard reaction might accumulate in larger amounts in the nucleus and cortex than in the capsule, resulting in the formation of cataracts. Expand
Inhibitory effects of tenilsetam on the Maillard reaction.
Tenilsetam inhibited glucose- and fructose-induced polymerization of lysozyme in a concentration-dependent manner in vitro and suggested its potential therapeutic role in controlling diabetic complications. Expand
Acceleration of Fructose Mediated Collagen Glycation
Fructose in the polyol pathway plays an important role in the formation of advanced Maillard reaction products which show fluorescence and have crosslinking, and collagen was significantly less soluble than after incubation with glucose. Expand
Hb Himeji or beta 140 (H18) Ala----Asp. A slightly unstable hemoglobin with increased beta N-terminal glycation.
A fast-moving abnormal hemoglobin found in a diabetic patient was identified as beta 140 (H18) Ala----Asp. It comprised about 40% of the total hemoglobin. The beta N-terminal glycation in theExpand
An outbreak of fulminant hepatitis B in immunocompromised hemodialysis patients
This outbreak of fulminant hepatitis B suggests that hemodialysis patients can foster highly virulent HBV strains (possibly owing to their compromised immune responses), which may place others at risk of severe, life-threatening acute liver damage and at increased risk of mortality if chronic carriers of HCV should be infected. Expand