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Distinct Diversity of vacA, cagA, and cagE Genes of Helicobacter pylori Associated with Peptic Ulcer in Japan
ABSTRACT Colonization of the stomach mucosa by Helicobacter pylori is a major cause of acute and chronic gastric pathologies in humans. Several H. pylori virulence genes that may play a role in itsExpand
Association between diversity in the Src homology 2 domain--containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer.
We investigated the relationship between the diversity of Helicobacter pylori CagA protein and clinical outcome. The cagA gene was sequenced in 115 clinical isolates. The binding affinity of CagA toExpand
Isolation and characterization of bioactive peptides from the sea cucumber, Stichopus japonicus
In the previous study, we isolated a number of bioactive peptides from the body wall of the sea cucumber, Stichopus japonicus, and determined the primary structures of four species of the isolatedExpand
The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa.
Recent experiments have indicated that CagA of Helicobacter pylori is injected into epithelial cells via the type IV secretion system and undergoes tyrosine phosphorylation in cells and thatExpand
Eradication of Helicobacter pylori infection induces an increase in body mass index
The relationship between H. pylori infection and body mass indices is controversial.
Hym-301, a novel peptide, regulates the number of tentacles formed in hydra
Hym-301 is a peptide that was discovered as part of a project aimed at isolating novel peptides from hydra. We have isolated and characterized the gene Hym-301, which encodes this peptide. In anExpand
Isolation and characterization of a novel bioactive peptide, Carassius RFamide (C-RFa), from the brain of the Japanese crucian carp.
A novel bioactive peptide with the C-terminal RFamide was isolated from the brain of the Japanese crucian carp, Carassius auratus langsdorfii, by using the intestine of the fish as the bioassayExpand
Gastric leptin and Helicobacter pyloriinfection
BACKGROUND Leptin regulates feeding behaviour and therefore may be a mediator of anorexia associated with acute and chronic inflammation. Recently, leptin mRNA and leptin protein were found in theExpand
Correlation between variation of the 3' region of the cagA gene in Helicobacter pylori and disease outcome in Japan.
Genetic diversity within the cag pathogenicity island (PAI) of Helicobacter pylori may have a modifying effect on the pathogenic potential of the infecting strain. The genetic structure of the cagExpand