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CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.
The SMG-1-mediated phosphorylation of Upf1 occurs on the association of SURF with EJC, which provides the link between the EJC and recognition of PTCs and triggers NMD.
PHAX, a Mediator of U snRNA Nuclear Export Whose Activity Is Regulated by Phosphorylation
RanGTP-Regulated Interactions of CRM1 with Nucleoporins and a Shuttling DEAD-Box Helicase
Using a quantitativeCRM1-NES cargo binding assay, significant differences in affinity for CRM1 among natural NESs are demonstrated, suggesting that the steady-state nucleocytoplasmic distribution of shuttling proteins could be determined by the relative strengths of their NESs.
Crystal structure of the human nuclear cap binding complex.
ATP-Dependent Recruitment of Export Factor Aly/REF onto Intronless mRNAs by RNA Helicase UAP56
It is shown that Aly/REF could preferentially bind intronless mRNAs in vitro and that this binding was stimulated by RNA helicase UAP56 in an ATP-dependent manner, which provides a mechanistic insight into how export factors are recruited onto m RNAs.
Nucleocytoplasmic transport: Ran, beta and beyond.
Nucleocytoplasmic Transport: The Last 200 Nanometers
A role for ubiquitin in the clearance of nonfunctional rRNAs.
The results uncovered an unexpected connection between DNA repair and the quality control of rRNAs and revealed that a group of proteins associated with nonfunctional ribosome particles are ubiquitinated in a Rtt101-Mms1-dependent manner.
Mutations Conferring Resistance to Human Immunodeficiency Virus Type 1 Fusion Inhibitors Are Restricted by gp41 and Rev-Responsive Element Functions
HIV acquired resistance to C34 by mutations in N-HR, which directly interacted with C34, however, since this region also encoded the RRE, additional mutations were required to maintain viral replication.